Effects of combined aerobic exercise and diet on cardiometabolic health in patients with obesity and type 2 diabetes: a systematic review and meta-analysis

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dc.authoridYagin, Fatma Hilal/0000-0002-9848-7958
dc.authoridAlhussain, Maha/0000-0003-0168-6721
dc.authoridAldhahi, Monira I./0000-0002-5255-4860
dc.authoridBatrakoulis, Alexios/0000-0003-0844-1284
dc.authoridAlhussain, Maha H/0000-0003-0168-6721
dc.authorwosidYagin, Fatma Hilal/ABI-8066-2020
dc.authorwosidAlhussain, Maha/AAV-8065-2021
dc.authorwosidAldhahi, Monira I./ABF-6238-2021
dc.authorwosidBatrakoulis, Alexios/AAE-4820-2022
dc.authorwosidAlhussain, Maha H/ABC-3652-2020
dc.contributor.authorAl-Mhanna, Sameer Badri
dc.contributor.authorRocha-Rodriguesc, Silvia
dc.contributor.authorMohamed, Mahaneem
dc.contributor.authorBatrakoulis, Alexios
dc.contributor.authorAldhahi, Monira I.
dc.contributor.authorAfolabi, Hafeez Abiola
dc.contributor.authorYagin, Fatma Hilal
dc.date.accessioned2024-08-04T20:54:55Z
dc.date.available2024-08-04T20:54:55Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground Lifestyle modifications involving diet and exercise are recommended for patients diagnosed with obesity and type 2 diabetes mellitus (T2DM). The purpose of this review was to systematically evaluate the effects of combined aerobic exercise and diet (AEDT) on various cardiometabolic health-related indicators among individuals with obesity and T2DM.Methodology A comprehensive search of the PubMed/Medline, Web of Science, Scopus, Science Direct, Cochrane, and Google Scholar databases was conducted for this meta-analysis. The Cochrane risk of bias tool was used to evaluate eligible studies, and the GRADE tool was used to rate the certainty of evidence. A random-effects model for continuous variables was used, and the results were presented as mean differences or standardised mean differences with 95% confidence intervals.Results A total of 16,129 studies were retrieved; 20 studies were included, and data were extracted from 1,192 participants. The findings revealed significant improvements in body mass index, body weight, waist circumference, systolic blood pressure, diastolic blood pressure, total cholesterol, triglycerides, fasting blood glucose, fasting plasma insulin, glycated hemoglobin, leptin, interleukin-6, C-reactive protein, and adiponectin (p < 0.05) compared to the standard treatment (ST) group. No significant differences were observed between the AEDT and ST groups in fat mass, hip circumference, waist-to-hip ratio, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and tumor necrosis factor-alpha. The present findings are based on low- to moderate-quality evidence.Conclusions AEDT may be a critical behavior for holistic cardiometabolic health-related benefits as a contemporary anti-obesity medication due to its significant positive impact on patients with obesity and T2DM. Nevertheless, further robust evidence is necessary to determine whether AEDT is an effective intervention for lowering cardiovascular and metabolic risk factors among individuals with obesity and T2DM.en_US
dc.description.sponsorshipPrincess Nourah Bint Abdulrahman University [304]; School of Medical Sciences at the Universiti Sains Malaysiaen_US
dc.description.sponsorshipThe authors acknowledge the School of Medical Sciences at the Universiti Sains Malaysia for the support in this project (No.: 304.PPSP.6315639).en_US
dc.identifier.doi10.1186/s13102-023-00766-5
dc.identifier.issn2052-1847
dc.identifier.issue1en_US
dc.identifier.pmid38049873en_US
dc.identifier.scopus2-s2.0-85178429850en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1186/s13102-023-00766-5
dc.identifier.urihttps://hdl.handle.net/11616/101698
dc.identifier.volume15en_US
dc.identifier.wosWOS:001113726400002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofBmc Sports Science Medicine and Rehabilitationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPhysical activityen_US
dc.subjectExerciseen_US
dc.subjectOverweighten_US
dc.subjectMetabolic syndromeen_US
dc.subjectLifestyle interventionen_US
dc.titleEffects of combined aerobic exercise and diet on cardiometabolic health in patients with obesity and type 2 diabetes: a systematic review and meta-analysisen_US
dc.typeReview Articleen_US

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