Anticancer activities of manganese-based photoactivatable CO-releasing complexes (PhotoCORMs) with benzimidazole derivative ligands

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dc.authoridÖzdemir, İsmail/0000-0001-6325-0216
dc.authoridÜstün, Elvan/0000-0002-0587-7261
dc.authoridDüşünceli, Serpil Demir/0000-0001-8765-4039
dc.authoridTUTAR, Yusuf/0000-0003-2613-9644
dc.authorwosidÖzdemir, İsmail/ABI-5192-2020
dc.authorwosidDemir, Serpil/AAI-1740-2019
dc.authorwosidTutar, Yusuf/JUV-7385-2023
dc.authorwosidÜstün, Elvan/HJB-1157-2022
dc.authorwosidÖzgür, Aykut/AAE-4823-2022
dc.authorwosidDüşünceli, Serpil Demir/AAA-7160-2021
dc.contributor.authorUstun, Elvan
dc.contributor.authorOzgur, Aykut
dc.contributor.authorCoskun, Kubra A.
dc.contributor.authorDusunceli, Serpil Demir
dc.contributor.authorOzdemir, Ismail
dc.contributor.authorTutar, Yusuf
dc.date.accessioned2024-08-04T20:43:02Z
dc.date.available2024-08-04T20:43:02Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCarbon monoxide is an important signaling molecule which is produced by heme oxygenase-1. CO shows antiproliferative activity against cancer cells; hence, activation of HO-1 is a significant inhibition strategy against tumor formation and survival of cancer cells. In this work, manganese-based CO-releasing molecules (CORMs) were designed and synthesized to inhibit breast cancer cell proliferation. Human invasive ductal breast cancer cells (MCF-7) were treated with the synthesized CORMs to investigate the effect of the complexes on breast cancer survival under UV light. In vitro experiments indicated that the complexes inhibited breast cancer cell proliferation, and further, the antiproliferative effects were increased under UV light. Thus, these novel CORMs may provide a drug template for the treatment of invasive ductal breast cancer.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [112T320]en_US
dc.description.sponsorshipThis work by Scientific and Technological Research Council of Turkey (TUBITAK, Project No: 112T320) is gratefully acknowledged.en_US
dc.identifier.doi10.1007/s11243-017-0136-x
dc.identifier.endpage337en_US
dc.identifier.issn0340-4285
dc.identifier.issn1572-901X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85016101346en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage331en_US
dc.identifier.urihttps://doi.org/10.1007/s11243-017-0136-x
dc.identifier.urihttps://hdl.handle.net/11616/97753
dc.identifier.volume42en_US
dc.identifier.wosWOS:000399456900007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofTransition Metal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHeme Oxygenase-1en_US
dc.subjectCarbon-Monoxideen_US
dc.subjectZinc Protoporphyrinen_US
dc.subjectNitric-Oxideen_US
dc.subjectCancer-Cellsen_US
dc.subjectTumor-Cellsen_US
dc.subjectInhibitionen_US
dc.subjectOverexpressionen_US
dc.subjectProliferationen_US
dc.subjectCytotoxicityen_US
dc.titleAnticancer activities of manganese-based photoactivatable CO-releasing complexes (PhotoCORMs) with benzimidazole derivative ligandsen_US
dc.typeArticleen_US

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