Urinary Neutrophil Gelatinase-Associated Lipocalin as an Early Biomarker for Prediction of Acute Kidney Injury in Preterm Infants

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dc.authoridİpek, Sevcan/0000-0002-1406-4895
dc.authoridözyalın, fatma/0000-0001-6486-6389
dc.authoridÖzyalın, Fatma/0000-0001-6486-6389
dc.authoridElmas, Ahmet Taner/0000-0002-9749-6115;
dc.authorwosidTabel, Yilmaz/AAF-9801-2020
dc.authorwosidİpek, Sevcan/AAG-5302-2021
dc.authorwosidözyalın, fatma/ABA-5258-2020
dc.authorwosidÖzyalın, Fatma/ABC-7193-2020
dc.authorwosidElmas, Ahmet Taner/ABI-1338-2020
dc.authorwosidELMAS, Ahmet Taner/W-4101-2017
dc.contributor.authorTabel, Yilmaz
dc.contributor.authorElmas, Ahmet
dc.contributor.authorIpek, Sevcan
dc.contributor.authorKaradag, Ahmet
dc.contributor.authorElmas, Ozlem
dc.contributor.authorOzyalin, Fatma
dc.date.accessioned2024-08-04T20:38:02Z
dc.date.available2024-08-04T20:38:02Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackgroundOur aims are to determine whether the urinary neutrophil gelatinase-associated lipocalin (uNGAL) can predict acute kidney injury (AKI) development in nonseptic and nonasphyxiated but critically ill preterm infants. MethodsFifty preterm infants, gestational age (GA) between 28 and 34 weeks, were included in this case control study. Blood and urine samples were taken for blood urea nitrogen, serum creatinine, and uNGAL on postnatal (PN) days 1 and 7. uNGAL levels were measured by enzyme-linked immunoassay. Clinical and laboratory characteristics of the AKI group were compared with the non-AKI group. ResultsAKI was diagnosed in six infants during the first week. The median uNGAL levels were significantly higher in the preterm infants with AKI than those of the controls on PN days 1 and 7 (p=0.006 and p=0.023, respectively). Backward stepwise logistic regression analysis identified that 5-minute Apgar score and uNGAL levels were significantly associated with the development of AKI, even after controlling for GA, birth weight, gender, and 1-minute Apgar score in nonseptic and nonasphyxiated but critically ill preterm infants. ConclusionsuNGAL can be useful as a predictive marker of AKI in nonseptic and nonasphyxiated but critically ill preterm infants.en_US
dc.identifier.doi10.1055/s-0033-1343770
dc.identifier.endpage173en_US
dc.identifier.issn0735-1631
dc.identifier.issn1098-8785
dc.identifier.issue2en_US
dc.identifier.pmid23592318en_US
dc.identifier.scopus2-s2.0-84893712677en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage167en_US
dc.identifier.urihttps://doi.org/10.1055/s-0033-1343770
dc.identifier.urihttps://hdl.handle.net/11616/96342
dc.identifier.volume31en_US
dc.identifier.wosWOS:000331195200012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherThieme Medical Publ Incen_US
dc.relation.ispartofAmerican Journal of Perinatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpretermen_US
dc.subjectinfanten_US
dc.subjectacute kidney injuryen_US
dc.subjecturinary neutrophil gelatinase-associated lipocalinen_US
dc.titleUrinary Neutrophil Gelatinase-Associated Lipocalin as an Early Biomarker for Prediction of Acute Kidney Injury in Preterm Infantsen_US
dc.typeArticleen_US

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