Improving effects of aminoguanidine on the histologic alterations in rat kidneys in diabetes

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dc.authorscopusid7004559930
dc.authorscopusid6602939148
dc.authorscopusid55807973900
dc.authorscopusid7004301483
dc.authorscopusid56244596600
dc.authorscopusid6506422932
dc.contributor.authorVardi N.
dc.contributor.authorIraz M.
dc.contributor.authorGül M.
dc.contributor.authorÖztürk F.
dc.contributor.authorUçar M.
dc.contributor.authorOtlu A.
dc.date.accessioned2024-08-04T20:00:54Z
dc.date.available2024-08-04T20:00:54Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: This study was designed to investigate the improving effects of aminoguanidine on renal histological alterations in a streptozotocin (STZ)- induced diabetic rat model. Material and Methods: Fifteen Sprague-Dawley adult female rats were divided into three groups: control, diabetic (D) and diabetic treatment with aminoguanidine (DAG) groups. Experimental diabetes was induced by a single intraperitoneal dose of STZ (45 mg/kg). In the DAG group, AG was added in the drinking water (1 gr/L) after administration of STZ. This was maintained until the end of the study (for 8 weeks). At the end of the experiment, blood glucose levels were determined and after the routine tissue follow-up process, kidneys were embedded in paraffin. Histochemical and immunohistochemical stains were applied and the specimens were examined with light microscope. Results: After 8 weeks, the rats in diabetes group had significantly lower body weight and significantly higher blood glucose levels than the rats of control and DAG groups. The main histological changes resulting from diabetes were detected in glomerular and tübüler basal membrane and epithelial cells (glycogen accumulation, swelling and vacuolization). We observed the improving effects of aminoguanidine treatment on rat kidney. Conclusion: In conclusion, chronic administration of aminoguanidine reduced renal injury in STZ- induced diabetic rats. Therefore, we believe that aminoguanidine may be used to prevent development of diabetic renal damage. However, further studies are needed to elucidate the mechanisms of the improving effect of aminoguanidine on diabetic complications. Copyright © 2006 by Türkiye Klinikleri.en_US
dc.identifier.endpage606en_US
dc.identifier.issn1300-0292
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-33846007697en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage599en_US
dc.identifier.urihttps://hdl.handle.net/11616/91106
dc.identifier.volume26en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes mellitusen_US
dc.subjectExperimentalen_US
dc.subjectHistologyen_US
dc.subjectKidneyen_US
dc.subjectPimagedineen_US
dc.titleImproving effects of aminoguanidine on the histologic alterations in rat kidneys in diabetesen_US
dc.title.alternativeDiyabetin böbreklerde neden oldu?u histolojik de?işiklikler üzerine aminoguanidinin i?yileş tirici etkilerien_US
dc.typeArticleen_US

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