COVID-19 is more dangerous for older people and its severity is increasing: a case-control study

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dc.authoridTOSUN, Mustafa/0000-0002-5204-2099
dc.authoridKantarci, Mecit/0000-0002-1043-6719
dc.authoridMertoglu, Cuma/0000-0003-3497-4092
dc.authoridHUYUT, Mehmet Tahir/0000-0002-2564-991X
dc.authorwosidTOSUN, Mustafa/ABC-5421-2021
dc.authorwosidKantarci, Mecit/HLQ-6851-2023
dc.authorwosidMertoglu, Cuma/A-3506-2017
dc.contributor.authorMertoglu, Cuma
dc.contributor.authorHuyut, Mehmet Tahir
dc.contributor.authorOlmez, Hasan
dc.contributor.authorTosun, Mustafa
dc.contributor.authorKantarci, Mecit
dc.contributor.authorCoban, Taha Abdulkadir
dc.date.accessioned2024-08-04T20:50:48Z
dc.date.available2024-08-04T20:50:48Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCoronavirus disease 2019 (COVID-19) triggers important changes in routine blood tests. In this retrospective case-control study, biochemical, hematological and inflammatory biomarkers between March 10, 2020, and November 30, 2020 from 3969 COVID-19 patients (3746 in the non-intensive care unit (non-ICU) group and 223 in the ICU group) were analyzed by dividing into three groups as spring, summer and autumn. In the non-ICU group, lymphocyte to monocyte ratio was lower in autumn than the other two seasons and neutrophil to lymphocyte ratio was higher in autumn than the other two seasons. Also, monocyte and platelet were higher in spring than autumn; and eosinophil, hematocrit, hemoglobin, lymphocyte, and red blood cells decreased from spring to autumn. In the non-ICU group, alanine aminotransferase and gamma-glutamyltransferase gradually increased from spring to autumn, while albumin, alkaline phosphatase, calcium, total bilirubin and total protein gradually decreased. Additionally, C-reactive protein was higher in autumn than the other seasons, erythrocyte sedimentation rate was higher in autumn than summer. The changes in routine blood biomarkers in COVID-19 varied from the emergence of the disease until now. Also, the timely changes of blood biomarkers were mostly more negative, indicating that the disease progresses severely. The study was approved by the Erzincan Binali Yildirim University Non-interventional Clinical Trials Ethic Committee (approval No. 86041) on June 21, 2021.en_US
dc.identifier.doi10.4103/2045-9912.325992
dc.identifier.endpage54en_US
dc.identifier.issn2045-9912
dc.identifier.issue2en_US
dc.identifier.pmid34677152en_US
dc.identifier.scopus2-s2.0-85118213815en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage51en_US
dc.identifier.urihttps://doi.org/10.4103/2045-9912.325992
dc.identifier.urihttps://hdl.handle.net/11616/100289
dc.identifier.volume12en_US
dc.identifier.wosWOS:000726893200004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofMedical Gas Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbiochemicalen_US
dc.subjecthematological and inflammatory biomarkersen_US
dc.subjectneutrophil to lymphocyte ratioen_US
dc.subjectlymphocyte to monocyte ratioen_US
dc.subjectplatelet to lymphocyte ratioen_US
dc.subjectsystemic immune-inflammation indexen_US
dc.titleCOVID-19 is more dangerous for older people and its severity is increasing: a case-control studyen_US
dc.typeArticleen_US

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