High-fat and carbohydrate diet caused chronic kidney damage by disrupting kidney function, caspase-3, oxidative stress and inflammation

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dc.contributor.authorErdemli, Zeynep
dc.contributor.authorGul, Mehmet
dc.contributor.authorKayhan, Elif
dc.contributor.authorGokturk, Nurcan
dc.contributor.authorBag, Harika Gozukara
dc.contributor.authorErdemli, Mehmet Erman
dc.date.accessioned2024-08-04T20:55:07Z
dc.date.available2024-08-04T20:55:07Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe study aimed to compare the effects of a diet rich in fat, carbohydrates and protein on rat kidneys. The study was conducted on 40 Wistar albino rats bred at Ino center dot nu University Faculty of Medicine after the approval of the ethics committee. Rats were randomly divided into 4 groups: Control group, and the groups where the animals were fed with high carbohydrate, fat and protein rich feed. After the applications, the rat kidney tissues were removed by laparoscopy under anesthesia and blood samples were collected. 13 weeks long fat-rich and carbohydrate feed application had negative effects on oxidant-antioxidant balance, oxidative stress index, inflammation markers, kidney functions tests, histopathology and immunohistochemistry caspase-3 findings in rat kidney tissues, especially in the carbohydrate group when compared to the controls. Protein-rich feed, there were no significant difference in biochemical and histopathology compared to the control group. Fat and carbohydrate rich feed led to an increase in oxidative stress in rat kidney tissues. Oxidative stress led to nephrotoxicity, which in turn led to chronic kidney tissue damages. A more balanced and protein-rich diet instead of excessive sugar and fatty food intake could be suggested to prevent chronic kidney damage.en_US
dc.identifier.doi10.1016/j.prostaglandins.2024.106822
dc.identifier.issn1098-8823
dc.identifier.issn2212-196X
dc.identifier.pmid38395139en_US
dc.identifier.scopus2-s2.0-85186538628en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.prostaglandins.2024.106822
dc.identifier.urihttps://hdl.handle.net/11616/101856
dc.identifier.volume172en_US
dc.identifier.wosWOS:001199998900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofProstaglandins & Other Lipid Mediatorsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHigh fat dieten_US
dc.subjectHigh carbohydrate dieten_US
dc.subjectHigh protein dieten_US
dc.subjectChronic kidney diseaseen_US
dc.subjectOxidative stressen_US
dc.subjectInflammationen_US
dc.titleHigh-fat and carbohydrate diet caused chronic kidney damage by disrupting kidney function, caspase-3, oxidative stress and inflammationen_US
dc.typeArticleen_US

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