Induced angiogenesis with intramedullary direct current: experimental research

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dc.authoridAlat, Ilker/0000-0003-1860-7620
dc.authoridKutlu, Ramazan/0000-0001-7941-7025
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridInan, Mehmet/0000-0003-1806-7927
dc.authorwosidAlat, Ilker/AAQ-6262-2021
dc.authorwosidKutlu, Ramazan/B-1624-2016
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidInan, Mehmet/Q-6453-2019
dc.contributor.authorInan, M
dc.contributor.authorAlat, I
dc.contributor.authorGurses, I
dc.contributor.authorKekilli, E
dc.contributor.authorKutlu, R
dc.contributor.authorEskin, A
dc.contributor.authorAydin, OM
dc.date.accessioned2024-08-04T20:13:42Z
dc.date.available2024-08-04T20:13:42Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe purpose of this study was to evaluate angiogenesis after the use of intramedullary direct electrical current in rabbit tibia. Thirty-two New Zealand rabbits were divided into four groups: group 1, false electrode group; group 2, hole group; group 3, control group; and group 4, intramedullary electrical stimulation group. One-half of the rabbits in each group were evaluated angiographically, pathologically, and scintigraphically on day 7, and the rest were evaluated on day 21. Results proved that electrical stimulation was not capable of the induction of angiogenesis in the subjects killed on day 7 and day 21. Furthermore, we found some fibrotic changes secondary to electrical stimulation on day 7 ( P = 0.04) and day 21 ( P = 0.01). However, an increase in new capillary vessels occurred in the false electrode group ( P = 0.02). We found no useful effect of electrical stimulation in our study, a finding that is possibly due to our use of a method previously undocumented in the literature. We believe that this study can be the new baseline for further studies into the stimulation or inhibition of angiogenesis using intramedullary wire with or without electrical stimulation.en_US
dc.identifier.doi10.1152/ajpheart.01222.2003
dc.identifier.endpageH709en_US
dc.identifier.issn0363-6135
dc.identifier.issn1522-1539
dc.identifier.issue2en_US
dc.identifier.pmid15471970en_US
dc.identifier.scopus2-s2.0-12344337118en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageH705en_US
dc.identifier.urihttps://doi.org/10.1152/ajpheart.01222.2003
dc.identifier.urihttps://hdl.handle.net/11616/93791
dc.identifier.volume288en_US
dc.identifier.wosWOS:000226358800029en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Physiological Socen_US
dc.relation.ispartofAmerican Journal of Physiology-Heart and Circulatory Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmedullary canalen_US
dc.subjectAlat's transparencyen_US
dc.subjectK-wireen_US
dc.titleInduced angiogenesis with intramedullary direct current: experimental researchen_US
dc.typeArticleen_US

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