A life-saving therapy in Class I HELLP syndrome: Therapeutic plasma exchange

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dc.authoridKAYA, Emin/0000-0001-8605-8497
dc.authoridBERBER, Ilhami/0000-0003-3312-8476
dc.authoridErkurt, Mehmet Ali/0000-0002-3285-417X
dc.authorwosidKAYA, Emin/W-2951-2017
dc.authorwosidBERBER, Ilhami/ABI-6231-2020
dc.authorwosidErkurt, Mehmet Ali/ABI-7232-2020
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorBerber, Ilhami
dc.contributor.authorBerktas, Haci Bayram
dc.contributor.authorKuku, Irfan
dc.contributor.authorKaya, Emin
dc.contributor.authorKoroglu, Mustafa
dc.contributor.authorNizam, Ilknur
dc.date.accessioned2024-08-04T20:40:17Z
dc.date.available2024-08-04T20:40:17Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHELLP syndrome, which can affect multiple organ systems and cause maternal and fetal mortality, is a serious complication of pregnancy characterized by microangiopathic hemolytic anemia, elevation of liver enzymes, and thrombocytopenia. Delivering the infant usually suffices for the treatment of this syndrome. In cases with Class I HELLP syndrome, however, the clinical picture may rapidly deteriorate despite delivery. In this paper we presented the outcomes with the use of therapeutic plasma exchange in cases with class I HELLP syndrome. This study included 21 patients diagnosed with the Class I HELLP syndrome at Inonu University Faculty of Medicine, Department of Hematology between 2011 and 2014. A central venous catheter was placed and plasma exchange therapy was begun in patients unresponsive to delivery, steroid, and supportive therapy (blood and blood products, antihypertensive therapy, intravenous fluid administration, and antibiotics) within 24 hours after the diagnosis of Class I HELLP syndrome according to the Mississippi Criteria. All patients underwent therapeutic plasma exchange for three sessions each with a 1:1 volume. Hemogram and biochemical parameters of the patients were evaluated before and after the procedure. According to results, there was a statistically significant decrease in total bilirubin, LDH, AST, and ALT levels whereas a significant increase in platelet count was observed. Hemoglobin levels were increased, although this increase was not statistically significant. HELLP syndrome is primarily treated with the delivery of infant; however, some cases may show disease progression despite completion of delivery. As a potential cause of both maternal and fetal mortality, HELLP syndrome condition should be aggressively treated. Therapeutic plasma exchange is one of the available treatment options. Our study has found that postpartum use of plasma exchange therapy within 24 hours is an efficient and lifesaving treatment choice in Class I HELLP syndrome. (C) 2014 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.transci.2014.12.026
dc.identifier.endpage198en_US
dc.identifier.issn1473-0502
dc.identifier.issue2en_US
dc.identifier.pmid25595543en_US
dc.identifier.scopus2-s2.0-84930486575en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage194en_US
dc.identifier.urihttps://doi.org/10.1016/j.transci.2014.12.026
dc.identifier.urihttps://hdl.handle.net/11616/96810
dc.identifier.volume52en_US
dc.identifier.wosWOS:000356738500012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTransfusion and Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHELLP syndromeen_US
dc.subjectTherapeutic plasma exchangeen_US
dc.titleA life-saving therapy in Class I HELLP syndrome: Therapeutic plasma exchangeen_US
dc.typeArticleen_US

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