Antioxidant enzyme activities and oxidative stress in affective disorders

dc.authorwosidÖZEROL, ELİF/AAA-6707-2021
dc.contributor.authorOzcan, ME
dc.contributor.authorGulec, M
dc.contributor.authorOzerol, E
dc.contributor.authorPolat, R
dc.contributor.authorAkyol, O
dc.date.accessioned2024-08-04T20:13:47Z
dc.date.available2024-08-04T20:13:47Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description2nd International Meeting on Free Radicals in Health and Disease -- MAY 08-12, 2002 -- ISTANBUL, TURKEYen_US
dc.description.abstractRecent data from several reports indicate that free radicals are involved in the biochemical mechanisms underlying neuropsychiatric disorders in human. The results of several reports suggest that lower antioxidant defences against lipid peroxidation exist in patients with depression and that there is a therapeutic benefit from antioxidant supplementation in unstable manic-depressive patients. We investigated the antioxidant enzyme status and the indices of oxidative stress and lipid peroxidation end products in erythrocytes from patients with affective disorder. For this purpose, we measured superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities, as well as malondialdehyde (MDA) and nitric oxide (NO) levels in patients with affective disorders (n=30) in both pre- and post-treatment periods, and in a control group (n = 21). CAT activities were significantly decreased in both pre-, and post-treatment periods in patients compared to the control group. GSH-Px activity in the pre-treatment period in the patients was significantly lower than both post-treatment patient and control groups. MDA levels were increased in both pre-, and post-treatment patient groups compared to the control group. NO level was lower in the pre-treatment patient group than in the control group. There were statistically significant correlations between SOD and MDA, and SOD and NO in the pre-treatment patient and control groups. Because the overall study sample was small, and the post-treatment patient group was even smaller, it can tentatively be suggested that the antioxidant system is impaired during a mood episode in patients with affective disorders, normalizing at the end of the episode. (C) 2004 Lippincott Williams Wilkins.en_US
dc.identifier.doi10.1097/01.yic.0000110796.97676.89
dc.identifier.endpage95en_US
dc.identifier.issn0268-1315
dc.identifier.issn1473-5857
dc.identifier.issue2en_US
dc.identifier.pmid15076017en_US
dc.identifier.scopus2-s2.0-1542299043en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://doi.org/10.1097/01.yic.0000110796.97676.89
dc.identifier.urihttps://hdl.handle.net/11616/93846
dc.identifier.volume19en_US
dc.identifier.wosWOS:000220082300006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofInternational Clinical Psychopharmacologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectaffective disordersen_US
dc.subjectcatalaseen_US
dc.subjectglutathione peroxidaseen_US
dc.subjectmalondialdehydeen_US
dc.subjectnitric oxideen_US
dc.subjectsuperoxide dismutaseen_US
dc.titleAntioxidant enzyme activities and oxidative stress in affective disordersen_US
dc.typeConference Objecten_US

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