Protective Effect of Dexpanthenol on Ischemia-Reperfusion-Induced Renal Injury in Rats

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dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridBeytur, Ali/0000-0002-7870-3318
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridODABAS, Gul Pelin/0000-0003-4242-1789
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468;
dc.authorwosidPolat, Alaadin/Q-4052-2018
dc.authorwosidBeytur, Ali/AAA-2823-2021
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidODABAS, Gul Pelin/IYS-2970-2023
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorAltintas, Ramazan
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorBeytur, Ali
dc.contributor.authorVardi, Nigar
dc.contributor.authorPolat, Alaadin
dc.contributor.authorSagir, Mustafa
dc.contributor.authorOdabas, Gul Pelin
dc.date.accessioned2024-08-04T20:36:12Z
dc.date.available2024-08-04T20:36:12Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/Aims: This experimental study was designed to investigate protective and therapeutic effects of Dexpanthenol (Dxp), an alcoholic analogue of pantothenic acid, on kidney damage induced by ischemia-reperfusion (I/R) in rats. Methods: Forty rats were randomly divided into a control group and 4 I/R groups (1 h ischemia followed by 23 h reperfusion). Three I/R groups were treated by Dxp (500 mg/kg, i.p.) at 3 different time points (before ischemia, during ischemia and late reperfusion). The histopathological findings including apoptotic changes, and also tissue malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), blood urea nitrogen (BUN), serum creatinine (Cr) and albumin (Alb) levels were determined. Results: Kidney tissue MDA levels were found to be significantly higher in the I/R group, whereas the values of GPX were lower when compared to the control group. The levels of SOD and CAT did not reach to statistical meaning level in I/R group. Dxp given during ischemia reduced the elevated MDA levels to the nearly control levels and this ameliorating effect was found as parallel to the result of GPX. Serum levels of BUN and Cr were significantly higher in I/R group. Dxp given during ischemia significantly reduced the elevated BUN and Cr levels when compared to I/R group. Renal I/R injury also induced extensive tubular necrosis, glomerular damage and apoptosis in the histological evaluation. Dxp ameliorated these histological damages in different amounts in all treatment groups. Conclusion: In this study the protective effects of Dxp against renal I/R injury has been evaluated for the first time. Copyright (c) 2012 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000343411
dc.identifier.endpage230en_US
dc.identifier.issn1420-4096
dc.identifier.issn1423-0143
dc.identifier.issue1en_US
dc.identifier.pmid23147260en_US
dc.identifier.scopus2-s2.0-84868609452en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage220en_US
dc.identifier.urihttps://doi.org/10.1159/000343411
dc.identifier.urihttps://hdl.handle.net/11616/95850
dc.identifier.volume36en_US
dc.identifier.wosWOS:000318486400022en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofKidney & Blood Pressure Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDexpanthenolen_US
dc.subjectIschemia-reperfusionen_US
dc.subjectKidneyen_US
dc.subjectOxidative stressen_US
dc.subjectRaten_US
dc.titleProtective Effect of Dexpanthenol on Ischemia-Reperfusion-Induced Renal Injury in Ratsen_US
dc.typeArticleen_US

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