Recent Progress in Anticonvulsant Drug Research: Strategies for Anticonvulsant Drug Development and Applications of Antiepileptic Drugs for Non-Epileptic Central Nervous System Disorders

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dc.authoridKarakurt, Arzu/0000-0003-2209-0871
dc.authorwosidKarakurt, Arzu/ABH-9340-2020
dc.contributor.authorDalkara, Sevim
dc.contributor.authorKarakurt, Arzu
dc.date.accessioned2024-08-04T20:35:52Z
dc.date.available2024-08-04T20:35:52Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMajor advances in antiepileptic drug therapy have taken place since 1950s. In the first period, several antiepileptic drugs (AEDs) such as phenobarbital, diphenylhydantoin, ethosuximide, carbamazepine, benzodiazepines and valproic acid were introduced to epilepsy treatment. After 1990 many new generation drugs (lamotrigine, topiramate, gabapentine, pregabaline, felbamate, lacosamide, levetiracetam etc.) have been developed. These novel AEDs have offered some advantages such as fewer side effects, fewer drug-drug interactions, and better pharmacokinetic properties. But pharmacoresistance and therapeutic failure in 20-25% of the patients remain the main reasons to continue efforts to find safer and more efficacious drugs and ultimate a treatment for this devastating disease. Several AEDs especially novel compounds have been found to be effective also in the treatment of several other neurologic and psychiatric disorders. Chemical diversity of the newer antiepileptic drugs as well as those currently in clinical development is another point that encourages medicinal chemists to study this subject. This review summarizes recent studies on the development of potential anticonvulsant compounds in different chemical structures, their structure-activity relationships and also therapeutic usages of AEDs other than epilepsy.en_US
dc.identifier.doi10.2174/156802612800229215
dc.identifier.endpage1071en_US
dc.identifier.issn1568-0266
dc.identifier.issn1873-5294
dc.identifier.issue9en_US
dc.identifier.pmid22352861en_US
dc.identifier.scopus2-s2.0-84860487059en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1033en_US
dc.identifier.urihttps://doi.org/10.2174/156802612800229215
dc.identifier.urihttps://hdl.handle.net/11616/95642
dc.identifier.volume12en_US
dc.identifier.wosWOS:000303060600006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Topics in Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntiepileptic drug development strategiesen_US
dc.subjectanticonvulsant drug researchen_US
dc.subjectnew anticonvulsant compoundsen_US
dc.subjectnonepileptic uses of AEDsen_US
dc.subjectQSARen_US
dc.titleRecent Progress in Anticonvulsant Drug Research: Strategies for Anticonvulsant Drug Development and Applications of Antiepileptic Drugs for Non-Epileptic Central Nervous System Disordersen_US
dc.typeReview Articleen_US

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