Association of biochemical and clinical parameters with parathyroid adenoma weight. Turkish-Bulgarian endocrine and breast surgery study group, hyperparathyroidism registry study

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dc.authoridEmre, Ali Ugur/0000-0002-1136-0517
dc.authoridErel, Serap/0000-0001-7365-883X;
dc.authorwosidEmre, Ali Ugur/JWA-0250-2024
dc.authorwosidErel, Serap/AAI-2387-2019
dc.authorwosidSoyder, Aykut/AAE-1969-2022
dc.authorwosidOzemir, Ibrahim Ali/M-2122-2018
dc.authorwosidOner, Gizem/AFQ-7970-2022
dc.authorwosidyıldız, ramazan/HFZ-9568-2022
dc.authorwosidCanturk, Nuh Zafer/AAS-3915-2020
dc.contributor.authorOzcinar, Beyza
dc.contributor.authorOner, Gizem
dc.contributor.authorMakay, Ozer
dc.contributor.authorSoyder, Aykut
dc.contributor.authorCanturk, N. Zafer
dc.contributor.authorUgurlu, M. Umit
dc.contributor.authorSezer, Y. Atakan
dc.date.accessioned2024-08-04T20:50:29Z
dc.date.available2024-08-04T20:50:29Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Primary hyperparathyroidism (pHPT) caused by a single benign parathyroid adenoma is a common endocrine disorder that is affected by regional differences. Living in different geographical regions reveals differences in the laboratory results and pathological findings, but studies on this subject are not sufficient. The article focuses on biochemical and pathological effects of geographical differences in parathyroid adenoma. In addition, the present study seeks to elaborate on treatment methods and effectiveness of screening in geographical area of Bulgaria and Turkey. Method: In this prospective study, 159 patients were included from 16 centres. Demographic characteristics, symptoms, biochemical markers and pathologic characteristics were analysed and compared between 8 different regions. Results: Patients from Turkish Black Sea had the highest median serum calcium (Ca) level, whereas patients from Eastern Turkey had the lowest median serum phosphorus (P) level. On the other hand, there was no significant difference between Ca, parathormone (PTH) and P levels according to regions. Patients from Eastern Turkey had the highest adenoma weight, while patients from Bulgaria had the lowest adenoma weight. The weight of adenoma showed statistically significant differences between regions (p < 0.001). There was a correlation between adenoma weight and serum PTH level (p = 0.05) and Ca level (p = 0.035). Conclusion: This study has provided a deeper insight into the effect of the regional differences upon clinicopathological changing and biochemical values of pHTP patients with adenoma. Awareness of regional differences will assist in biochemical screening and treatment of this patient group. (c) 2021 Asian Surgical Association and Taiwan Robotic Surgery Association. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).en_US
dc.identifier.doi10.1016/j.asjsur.2021.06.035
dc.identifier.endpage411en_US
dc.identifier.issn1015-9584
dc.identifier.issn0219-3108
dc.identifier.issue1en_US
dc.identifier.pmid34353709en_US
dc.identifier.scopus2-s2.0-85111671356en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage407en_US
dc.identifier.urihttps://doi.org/10.1016/j.asjsur.2021.06.035
dc.identifier.urihttps://hdl.handle.net/11616/100090
dc.identifier.volume45en_US
dc.identifier.wosWOS:000740945700023en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Singapore Pte Ltden_US
dc.relation.ispartofAsian Journal of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHyperparathyroidismen_US
dc.subjectRegional differencesen_US
dc.subjectAdenoma weighten_US
dc.subjectBiochemical markersen_US
dc.titleAssociation of biochemical and clinical parameters with parathyroid adenoma weight. Turkish-Bulgarian endocrine and breast surgery study group, hyperparathyroidism registry studyen_US
dc.typeArticleen_US

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