The effects of dental pulp stem cells on bone regeneration in rat calvarial defect model: Micro-computed tomography and histomorphometric analysis

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dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridPolat, Serkan/0000-0002-5814-5451
dc.authoridkahraman, sevil/0000-0003-3573-1068;
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidPolat, Serkan/M-2502-2013
dc.authorwosidKaraoz, Erdal/AAO-1470-2020
dc.authorwosidkahraman, sevil/HKE-3001-2023
dc.authorwosidPolat, Serkan/JAC-3478-2023
dc.contributor.authorAsutay, Fatih
dc.contributor.authorPolat, Serkan
dc.contributor.authorGul, Mehmet
dc.contributor.authorSubasi, Cansu
dc.contributor.authorKahraman, Sevil Altundag
dc.contributor.authorKaraoz, Erdal
dc.date.accessioned2024-08-04T20:41:16Z
dc.date.available2024-08-04T20:41:16Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Stem cell therapies may be applicable to all fields of medicine, including craniomaxillofacial surgery. Dental pulp stem cells also have significant osteogenic properties. This study aimed to evaluate the influence of dental pulp stem cells on bone regeneration and to ascertain whether or not there was any superiority over traditional methods. Design: In this study, 15 non-immunodeficient Wistar albino rats were used. The rats were divided into three groups: (1) untreated control group; (2) hydroxyapatite tri-calcium-phosphate (HA/TCP) paste; (3) human dental pulp derived stem cells (DPSC) mixed with HA/TCP paste (HA/TCP+DSPC group, n = 10). Two symmetrical full-thickness cranial defects were created on each parietal region (10 defects for each group). The animals were sacrificed 8 weeks post-surgery and samples were analyzed by microcomputer tomography (mu-CT) and histomorphometry. Results: The calcification rate and bone mineral density (BMD) values in Group 3 were found to be significantly higher than in the other two groups. Radiographically, bone regeneration was greater in Group 2 compared with the control group. However, there was no significant difference between Groups 2 and 1 in respect of histological analysis. Conclusions: According to the results of the present study, DPSCs may be a suitable factor for bone tissue engineering because they can be easily obtained and differentiate into bone cells. (C) 2015 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipInonu University, Department of Scientific Research Projects [2012/127]en_US
dc.description.sponsorshipThis study was supported by a research grant from Inonu University, Department of Scientific Research Projects (2012/127).en_US
dc.identifier.doi10.1016/j.archoralbio.2015.09.002
dc.identifier.endpage1735en_US
dc.identifier.issn0003-9969
dc.identifier.issn1879-1506
dc.identifier.issue12en_US
dc.identifier.pmid26433189en_US
dc.identifier.scopus2-s2.0-84943387108en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1729en_US
dc.identifier.urihttps://doi.org/10.1016/j.archoralbio.2015.09.002
dc.identifier.urihttps://hdl.handle.net/11616/97007
dc.identifier.volume60en_US
dc.identifier.wosWOS:000365065800005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofArchives of Oral Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTissue engineeringen_US
dc.subjectHuman dental pulp stem cellsen_US
dc.subjectBone regenerationen_US
dc.subjectHydroxyapatite-tri-calcium-phosphateen_US
dc.subjectCalvarial defectsen_US
dc.titleThe effects of dental pulp stem cells on bone regeneration in rat calvarial defect model: Micro-computed tomography and histomorphometric analysisen_US
dc.typeArticleen_US

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