Demographic and clinical properties of juvenile-onset Behcet's disease: A controlled multicenter study

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dc.authoridDurusoy, Çiçek/0000-0001-7952-4701
dc.authoridtürsen, ümit/0000-0002-5807-6759
dc.authoridALPSOY, ERKAN/0000-0001-7049-0170
dc.authoridÇİÇEK, DEMET/0000-0001-8405-7730
dc.authoridUzun, Soner/0000-0001-7059-5474
dc.authoridDonmez, Levent/0000-0002-5970-8658
dc.authorwosidDurusoy, Çiçek/AAT-7451-2021
dc.authorwosidAakman, A/C-3756-2016
dc.authorwosidtürsen, ümit/P-6626-2015
dc.authorwosidBORLU, MURAT/U-1593-2019
dc.authorwosidtopal, suhan g günaştı/U-3194-2018
dc.authorwosidALPSOY, ERKAN/C-1183-2016
dc.authorwosidÇİÇEK, DEMET/V-9829-2018
dc.contributor.authorKarincaoglu, Yelda
dc.contributor.authorBorlu, Murat
dc.contributor.authorToker, Sernra Cikman
dc.contributor.authorAkman, Ayse
dc.contributor.authorOnder, Meltem
dc.contributor.authorGunasti, Suhan
dc.contributor.authorUsta, Aysegul
dc.date.accessioned2024-08-04T20:30:43Z
dc.date.available2024-08-04T20:30:43Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Behcet's disease (BD) is a multisystemic inflammatory disorder Of unknown origin. The disease usually occurs between the second and the fourth decades, whereas it is uncommon in children. Objective. In this multicenter study, we aimed to describe the demographic and clinical features along with severity in juvenile- versus adult-onset 131). Methods: Patients with initial symptoms at age 16 years or younger were considered as having juvenileonset 131). In all, 83 patients with juvenile-onset BID (38 male and 45 female; mean age 19.6 +/- 7.6 years) and 536 with adult-onset (>16 years) BD (293 male and 243 female; mean age 39.2 +/- 10.1 years) who fulfilled the classification criteria of the International Study Group for BD were involved in the study. Results: Familial cases were more frequent in juvenile-onset compared with adult-onset BD (19% vs 10.3%; P=.017). The mean age of disease onset was 12.29 +/- 3.54 years in juvenile-onset 131) and 31.66 +/- 8.71 years in adult-onset 131). Mucocutaneous lesions and articular symptoms were the most commonly observed manifestations in both groups. The frequency of disease manifestations was not different between juvenile and adult-onset BID, except neurologic and gastrointestinal involvement, which were higher in juvenileonset 131) than adult-onset BD (P =.027 and P =.024, respectively). Oral ulcer was the most common onset manifestation of both juvenile-onset (86.74%) and adult-onset (89-55%) BD. The frequencies of onset manifestations of 131) were similar, except genital ulcer, which was higher in adult-onset 131) (P =.025). Limitations: Our study consisted of patients with 131) mainly applying to dermatology and venerology departments. Therefore, it can be speculated that this Study includes rather a milder spectrum of the disease. Conclusions: Although the clinical spectrum of juvenile-onset BD seems to be similar to adult-onset BD, the frequency of severe organ involvement was higher. Because of the higher prevalence of familial cases in juvenile-onset BD, it can be speculated that genetic factors may favor early expression of the disease with severe organ involvement.en_US
dc.identifier.doi10.1016/j.jaad.2007.10.452
dc.identifier.endpage584en_US
dc.identifier.issn0190-9622
dc.identifier.issue4en_US
dc.identifier.pmid18045733en_US
dc.identifier.scopus2-s2.0-40649103424en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage579en_US
dc.identifier.urihttps://doi.org/10.1016/j.jaad.2007.10.452
dc.identifier.urihttps://hdl.handle.net/11616/94482
dc.identifier.volume58en_US
dc.identifier.wosWOS:000254315000003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMosby-Elsevieren_US
dc.relation.ispartofJournal of The American Academy of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFeaturesen_US
dc.subjectChildrenen_US
dc.subjectEtiologyen_US
dc.titleDemographic and clinical properties of juvenile-onset Behcet's disease: A controlled multicenter studyen_US
dc.typeArticleen_US

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