The Assessment of Hepatosteatosis in Living-Donor Liver Transplant: Comparison of Liver Attenuation Index and Histopathologic Results

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dc.authoridKahraman, Aysegul Sagir/0000-0002-2147-1181
dc.authoridKahraman, Bayram/0000-0002-5447-1110
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridKarakas, Hakki/0000-0002-1328-8520
dc.authorwosidKahraman, Aysegul Sagir/S-1526-2016
dc.authorwosidKahraman, Bayram/HKM-4798-2023
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.contributor.authorKahraman, Aysegul Sagir
dc.contributor.authorKarakas, Hakki Muammer
dc.contributor.authorKirimlioglu, Hale
dc.contributor.authorKahraman, Bayram
dc.contributor.authorYilmaz, Sezai
dc.contributor.authorKirimlioglu, Vedat
dc.date.accessioned2024-08-04T20:42:56Z
dc.date.available2024-08-04T20:42:56Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: The purpose of the study was to determine the diagnostic value of computed tomography densitometry in the quantification of hepatosteatosis. Materials and Methods: Fifty-one potential liver donors, ranging in age from 19 to 52 years (mean age: 32.4 years +/- 10.2), participated in the study. The mean hepatic attenuation and mean splenic attenuation were determined using regions of interest measurements. The difference between the mean hepatic attenuation and mean splenic attenuation (or liver attenuation index), with liver attenuation index = mean hepatic attenuation - mean splenic attenuation were calcu lated. Computed tomography densitometric para meters were correlated with histopathologic results. Results: From the histopathologic analysis, the degree of macrovesicular hepatosteatosis was 0% to 8% (mean: 1.1% +/- 2%). Seven donors (13.7%) had a degree of macrovesicular steatosis of > 5%, and 12 donors (23.5%) had >= 2%. Of the 29 normal donors with histopathologic verification, computed tomography densitometry predicted <= 5% of the hepa to steatosis in 27 donors, and >= 2% hepato-steatosis in 2 subjects. The liver attenuation index was sig nificantly correlated to the histopathologic results. The mathematical relation between liver attenuation index and the degree of histopathologic hepatosteatosis was calculated using the least-squares methods, which provided quadratic polynomials. Conclusions: Computed tomography densitometry is a rapid, robust, noninvasive technique for the assessment of hepatosteatosis. When used in conjunction with clinically stable reference measurements of spleen, the density measurements of liver correctly predicted the presence of fatty infiltration with significant sensitivity (77%) and specificity (75%). This technique, which was refined during the course of our liver transplant program, minimizes the need for highly invasive percutaneous liver biopsies.en_US
dc.identifier.doi10.6002/ect.2015.0043
dc.identifier.endpage77en_US
dc.identifier.issn1304-0855
dc.identifier.issue1en_US
dc.identifier.pmid26221870en_US
dc.identifier.scopus2-s2.0-85011320215en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage69en_US
dc.identifier.urihttps://doi.org/10.6002/ect.2015.0043
dc.identifier.urihttps://hdl.handle.net/11616/97681
dc.identifier.volume15en_US
dc.identifier.wosWOS:000399334800011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBaskent Univen_US
dc.relation.ispartofExperimental and Clinical Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectComputed tomographyen_US
dc.subjectDensitometryen_US
dc.subjectHepatosteatosisen_US
dc.subjectLiving-donor liver transplanten_US
dc.titleThe Assessment of Hepatosteatosis in Living-Donor Liver Transplant: Comparison of Liver Attenuation Index and Histopathologic Resultsen_US
dc.typeArticleen_US

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