Effect of topical antibiotic prophylaxis on conjunctival flora and antibiotic resistance following intravitreal injections in patients with type 2 diabetes

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dc.authorscopusid55755921600
dc.authorscopusid35301469100
dc.authorscopusid45161508200
dc.authorscopusid58424634900
dc.authorscopusid57189224136
dc.contributor.authorKaldirim H.
dc.contributor.authorYazgan S.
dc.contributor.authorKirgiz A.
dc.contributor.authorOzdemir B.
dc.contributor.authorYilmaz A.
dc.date.accessioned2024-08-04T19:59:39Z
dc.date.available2024-08-04T19:59:39Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: We sought to determine changes in the conjunctival bacterial flora and antibiotic resistance after topical antibiotic drops for infection prophylaxis were administered following intravitreal injections in patients with type 2 diabetes. Methods: This prospective and nonrandomized cohort study included 116 eyes of 116 treatment-naive patients with type 2 diabetes who received six serial intravitreal anti-vascular endothelial growth factor injections for macular edema. Three conjunctival cultures were obtained from each eye over the course of the study (Culture 1, baseline; Culture 2, 1 month after the third injection; and Culture 3, 1 month after the sixth injection). The study subjects were given topical moxifloxacin hydrochloride for 4 days after each monthly intravitreal injection. The growth patterns of conjunctival bacterial flora and the antibiotic resistance to several commonly used antibiotics were examined. Results: The rate of culture positivity increased significantly during the observation period (Culture 1, n = 47, 40.5%; Culture 2, n = 58, 50%; Culture 3, n = 76, 65.5%, p < 0.001). The bacterium with the highest baseline culture positivity was Staphylococcus epidermidis (n = 45, 38.8%), which increased significantly during the observation period (p < 0.001). No significant increase was noted in the culture positivity of the other bacteria with baseline culture positivity (p > 0.05). Regarding antibiotic susceptibility, significant increases in resistance to the fluoroquinolone group of drugs were noted (p < 0.001). No significant changes in sensitivity were detected in the other 11 investigated antibiotics that are commonly used in clinical practice (p > 0.05). Conclusions: The use of topical moxifloxacin after each intravitreal injection significantly increases the fluoroquinolone resistance of the ocular surface flora and the culture-positivity rate of S. epidermidis in patients with type 2 diabetes. © 2020 The Korean Ophthalmological Societyen_US
dc.identifier.doi10.3341/KJO.2019.0144
dc.identifier.endpage273en_US
dc.identifier.issn1011-8942
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85091476040en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage265en_US
dc.identifier.urihttps://doi.org/10.3341/KJO.2019.0144
dc.identifier.urihttps://hdl.handle.net/11616/90799
dc.identifier.volume34en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKorean Ophthalmological Society (KOS)en_US
dc.relation.ispartofKorean Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntibacterial drug resistanceen_US
dc.subjectAntibiotic prophylaxisen_US
dc.subjectDiabetes mellitusen_US
dc.subjectIntravitreal injectionsen_US
dc.subjectMacular edemaen_US
dc.titleEffect of topical antibiotic prophylaxis on conjunctival flora and antibiotic resistance following intravitreal injections in patients with type 2 diabetesen_US
dc.typeArticleen_US

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