Lutein and zeaxanthin isomers may attenuate photo-oxidative retinal damage via modulation of G protein-coupled receptors and growth factors in rats

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dc.authoridsahin, nurhan/0000-0001-9487-1154
dc.authoridAkdemir, Fatih/0000-0002-5779-6631
dc.authoridOrhan, Cemal/0000-0003-4138-7689
dc.authoridGENCOGLU, HASAN/0000-0002-7716-552X
dc.authoridSahin, Kazim/0000-0001-9542-5244
dc.authoridTuzcu, Mehmet/0000-0002-1329-3143
dc.authorwosidsahin, nurhan/ABF-8007-2020
dc.authorwosidAkdemir, Fatih/AAG-8010-2019
dc.authorwosidOrhan, Cemal/Q-2086-2015
dc.authorwosidGENCOGLU, HASAN/Q-2668-2015
dc.authorwosidSahin, Kazim/D-5625-2009
dc.authorwosidTuzcu, Mehmet/H-2953-2018
dc.contributor.authorSahin, Kazim
dc.contributor.authorGencoglu, Hasan
dc.contributor.authorAkdemir, Fatih
dc.contributor.authorOrhan, Cemal
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorSahin, Nurhan
dc.contributor.authorYilmaz, Ismet
dc.date.accessioned2024-08-04T20:46:00Z
dc.date.available2024-08-04T20:46:00Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Retina photoreceptor cells are specially adapted for functioning over comprehensive ambient light conditions. Lutein and Zeaxanthin isomers (L/Zi) can protect photoreceptor cells against excessive light degeneration. Efficacy of L/Zi has been assessed on some G protein-coupled receptors (GPCRs), transcription and neurotrophic factors in the retina of rats exposed to incremental intense light emitting diode (LED) illumination conditions. Methods: Forty-two male rats (age: 8 weeks) were randomly assigned to six treatment groups, 7 rats each. The rats with a 3x2 factorial design were kept under 3 intense light conditions (12hL/12hD, 16hL/8hD, 24hL/OhD) and received two levels of L/Zi (0 or 100 mg/kg BW) for two months. Increased nuclear factor-kappa B (NF-kappa B), glial fibrillary acid protein (GFAP), and decreased Rhodopsin (Rho), Rod arrestin (Sag), G Protein Subunit Alpha Transducin1 (Gnat1), neural cell adhesion molecule (NCAM), growth associated protein-43 (GAP43), nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and heme oxygenase 1 (HO-1) were observed in 24 h light intensity adaptation followed by 16 h IL and 8 h D. Results: L/Zi administration significantly improved antioxidant capacity and retinal Rho, Rod-arrestin (Sag), Gnat1, NCAM, GAP43, BDNF, NGF, IG1, Nrf2, and HO-1 levels. However, the levels of NF-kappa B and GFAP levels were decreased by administration of L/Zi. Conclusions: According to these results, L/Zi may be assumed as an adjunct therapy to prevent early photoreceptor cell degeneration and neutralize free radicals derived from oxidative stress. (C) 2019 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipOmniActive Health Technologies (NJ, United States); Turkish Academy of Science (Ankara, Turkey)en_US
dc.description.sponsorshipThis study was supported by OmniActive Health Technologies (NJ, United States) and partially supported by the Turkish Academy of Science (Ankara, Turkey).en_US
dc.identifier.doi10.1016/j.bbrc.2019.06.032
dc.identifier.endpage170en_US
dc.identifier.issn0006-291X
dc.identifier.issn1090-2104
dc.identifier.issue1en_US
dc.identifier.pmid31204054en_US
dc.identifier.scopus2-s2.0-85067211358en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage163en_US
dc.identifier.urihttps://doi.org/10.1016/j.bbrc.2019.06.032
dc.identifier.urihttps://hdl.handle.net/11616/98830
dc.identifier.volume516en_US
dc.identifier.wosWOS:000476580800025en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarotenoidsen_US
dc.subjectGPCRsen_US
dc.subjectLight-emitting diodeen_US
dc.subjectNeurotrophinsen_US
dc.subjectPhoto-oxidationen_US
dc.subjectRetinaen_US
dc.titleLutein and zeaxanthin isomers may attenuate photo-oxidative retinal damage via modulation of G protein-coupled receptors and growth factors in ratsen_US
dc.typeArticleen_US

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