Preventive Effect of Chrysin on Bleomycin-Induced Lung Fibrosis in Rats

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dc.authoridKilic, Talat/0000-0001-8125-9062
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidKilic, Talat/ABI-4457-2020
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.contributor.authorKilic, Talat
dc.contributor.authorCiftci, Osman
dc.contributor.authorCetin, Asli
dc.contributor.authorKahraman, Hasan
dc.date.accessioned2024-08-04T20:40:21Z
dc.date.available2024-08-04T20:40:21Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of the current study is determination of protective effect of chrysin (CRS), a natural flavonoid, on cell injury produced by lung fibrosis induced with bleomycin (BLC) in rats. Twenty-eight female rats were assigned to four groups as follows: control group, CRS group; 50 mg/kg CRS was continued orally for 14 days, BLC group; a single intratracheal injection of BLC (2.5 mg/kg body weight in 0.25 ml phosphate buffered saline), BLC + CRS group; 50 mg/kg CRS was administered 1 day before the intratracheal BLC injection and continued for 14 days orally. All animals were sacrificed at day 14th after BLC administration. The semiquantitative assessment of histopathological consisting of lung inflammation and collagen deposition, tissue levels of thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reducted glutathione (GSH) were measured. BLC provoked histological changes consisting of alveolar congestion, increase connective tissue, infiltration, and the thickness of alveolar wall were detected significantly when compared to the control group (p a parts per thousand currency signaEuro parts per thousand 0.0001). CRS supplementation significantly restored these histological damages (p a parts per thousand currency signaEuro parts per thousand 0.0001). The level of tissue TBARS was increased with BLC (p < 0.01). Increased level of TBARS was significantly reversed by CRS administration. Also, BLC administration reduced tissue activities of SOD, GPx, CAT, and GSH in the lung tissue compared to control group (p < 0.01). Furthermore, the reduction in activities of CAT, SOD, and level of GSH were prevented by CRS supplementation (p < 0.01). In this study, we demonstrated for the first time that CRS significantly prevents BLC-induced lung inflammation and fibrosis in rats. Further studies are needed to assess the role of CRS in the treatment of lung inflammation and fibrosis.en_US
dc.identifier.doi10.1007/s10753-014-9946-6
dc.identifier.endpage2124en_US
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue6en_US
dc.identifier.pmid24973983en_US
dc.identifier.scopus2-s2.0-84937579921en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2116en_US
dc.identifier.urihttps://doi.org/10.1007/s10753-014-9946-6
dc.identifier.urihttps://hdl.handle.net/11616/96873
dc.identifier.volume37en_US
dc.identifier.wosWOS:000345008100025en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofInflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantiinflammatoryen_US
dc.subjectbleomycinen_US
dc.subjectchrysinen_US
dc.subjectpulmonary fibrosisen_US
dc.subjectidiopathic pulmonary fibrosisen_US
dc.titlePreventive Effect of Chrysin on Bleomycin-Induced Lung Fibrosis in Ratsen_US
dc.typeArticleen_US

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