Investigation of in vivo radioprotective and in vitro antioxidant and antimicrobial activity of garlic (Allium Sativum)

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dc.authoridSatilmis, Basri/0000-0002-2538-5774
dc.authoridSatilmis, Basri/0000-0002-2538-5774
dc.authoridBatcioglu, Kadir/0000-0001-6663-2287
dc.authoridUyumlu, Ayşe Burçin/0000-0001-9517-9274
dc.authoridYucel, Neslihan/0000-0001-5845-2614
dc.authoridGünal, Selami/0000-0002-4752-5176
dc.authorwosidSatilmis, Basri/JBR-9078-2023
dc.authorwosidSatilmis, Basri/C-5176-2019
dc.authorwosidBatcioglu, Kadir/Q-2424-2015
dc.authorwosidUyumlu, Ayşe Burçin/ABH-5573-2020
dc.authorwosidYucel, Neslihan/ABI-3412-2020
dc.authorwosidDogan, Zumrut yılmaz/V-5131-2018
dc.authorwosidErkal, Haldun Sukru/AAC-8209-2019
dc.contributor.authorBatcioglu, K.
dc.contributor.authorYilmaz, Z.
dc.contributor.authorSatilmis, B.
dc.contributor.authorUyumlu, A. B.
dc.contributor.authorErkal, H. S.
dc.contributor.authorYucel, N.
dc.contributor.authorGunal, S.
dc.date.accessioned2024-08-04T20:36:01Z
dc.date.available2024-08-04T20:36:01Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE, In this study, we aimed to assess the in vivo antioxidant potential via evaluating radioprotective effects in kidney and liver tissues of rats and in vitro antimicrobial and radical scavenger activity of garlic extract. MATERIALS AND METHODS, Thirty-two mature female Wistar rats were divided into four groups, each consisting of eight rats. Experimental groups were control group (1), GE group (2), irradiation group (3) and both GE and irradiation group (4). For the rats in two groups (group 3 and 4), irradiation was performed on a Cobalt-60 unit using a single fraction of 20 Gy. The GE was given to rats once a day during the month before irradiation and continued for five days after irradiation. The garlic cloves were peeled on crushed ice and 50 g of garlic was cut into small pieces and homogenized in 75 mL of 0.9% NaCl. The concentration of this garlic preparation was considered to be 500 mg/mL on the basis of weight of the starting material (0.5 g/mL). This extract was administered to rats by oral gavage. RESULTS, Our findings suggest that the use of garlic extract could be useful for addressing the limited therapeutic gain due to the radiation sensitivity of normal tissues adjacent to the tumour which are exposed to radiation, by strengthening the antioxidant system. In vitro and in vivo experiments seem to yield similar conclusions. CONCLUSIONS, It can be stated that garlic is may be recommended to be sufficiently included in the diets of radiotherapy patients considering its antioxidant and antimicrobial efficacy.en_US
dc.identifier.endpage57en_US
dc.identifier.issn1128-3602
dc.identifier.pmid22957418en_US
dc.identifier.scopus2-s2.0-84864265341en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://hdl.handle.net/11616/95738
dc.identifier.volume16en_US
dc.identifier.wosWOS:000307130900007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIrradiationen_US
dc.subjectGarlic extracten_US
dc.subjectOxidative damageen_US
dc.subjectAntimicrobialen_US
dc.titleInvestigation of in vivo radioprotective and in vitro antioxidant and antimicrobial activity of garlic (Allium Sativum)en_US
dc.typeArticleen_US

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