Sythesis, characterisation, anticancer and antimicrobial activity of Ag-N-heterocyclic carbene complexes containing benzimidazole derivatives

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dc.authoridDundar, Muhammed/0000-0001-6509-2012
dc.authoridKarci, Huseyin/0000-0002-5709-1623
dc.authorwosidDundar, Muhammed/AAN-1831-2020
dc.authorwosidOZDEMIR, ISMAIL/KVY-3420-2024
dc.authorwosidKarci, Huseyin/AAC-3985-2022
dc.contributor.authorKarci, Huseyin
dc.contributor.authorDundar, Muhammed
dc.contributor.authorNawaz, Zahid
dc.contributor.authorOzdemir, Lknur
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorKoc, Ahmet
dc.contributor.authorOzdemir, Ismail
dc.date.accessioned2024-08-04T20:55:07Z
dc.date.available2024-08-04T20:55:07Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTo prepare a novel series of silver(I) complexes, the interaction of benzimidazolium salts having their two nitrogen atoms substituted by bulky groups with Ag2O in DCM has been carried out. Their structures were characterized by elemental analyses, 1H NMR, 13C NMR, elemental analysis, and IR spectroscopy techniques. Further, the antimicrobial and antifungal activities properties of both the salts and their silver(I)-NHC complexes were tested against positive and negative bacteria using the Clinical and Laboratory Standards Institute (CLSI) and the European Committee for Antimicrobial Susceptibility Testing (EUCAST) respectively. The results show that silver complexes are effective against E. coli, P. aeruginosa and S. aureus bacterial species with moderate to high activity, and their minimum inhibitory concentrations ranging from 25 to 400 mu g/Ml. It was also observed that 3b compound, which has the best antifungal properties among the synthesized compounds, showed high antimicrobial activity when all bacterial species were taken into account. In addition, the salts and complexes were then evaluated for their ability to inhibit the proliferation of four different cancer cell lines (A549, MCF-7, HCT116, SH-SY5Y and BEAS-2B cells lines). AlamarBlue assay demonstrated that the salts and complexes exhibited potent cytotoxicity towards all cancer lines. 2c compound showed the highest cytotoxic activity against BEAS-2B, A549 and MCF-7 cell lines. Except for 2c, compounds 3d, 3e and 3f showed cytotoxic activity at the lowest concentrations against MCF7 cell line.The study highlights the importance of N-heterocyclic carbene ligands in the development of silver-based drugs with anticancer properties.en_US
dc.description.sponsorshipTechnological and Scientific Research Council of Turkey TUBITAK [120R030]; Inonue University Research Fund [FBG-2021-2562]; King Saud University, Riyadh, Saudi Arabia [RSP2024R75]en_US
dc.description.sponsorshipThis work was financially supported by: - The Technological and Scientific Research Council of Turkey TUBITAK (Project No: 120R030) and the Inonue University Research Fund (FBG-2021-2562).; - The authors extended their appreciation to the Researchers Supporting Project number (RSP2024R75), King Saud University, Riyadh, Saudi Arabia.en_US
dc.identifier.doi10.1016/j.ica.2024.121992
dc.identifier.issn0020-1693
dc.identifier.issn1873-3255
dc.identifier.scopus2-s2.0-85186370571en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.ica.2024.121992
dc.identifier.urihttps://hdl.handle.net/11616/101851
dc.identifier.volume565en_US
dc.identifier.wosWOS:001195605700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofInorganica Chimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN -Heterocyclic carbeneen_US
dc.subjectSilver(I) -NHC complexesen_US
dc.subjectAntimicrobial activityen_US
dc.subjectAnticancer activityen_US
dc.titleSythesis, characterisation, anticancer and antimicrobial activity of Ag-N-heterocyclic carbene complexes containing benzimidazole derivativesen_US
dc.typeArticleen_US

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