Evaluation of the toxicity and teratogenity of six commercial textile dyes using the frog embryo teratogenesis assay-Xenopus

dc.authoridBirhanlı, Ayşe/0000-0003-0870-1226
dc.authoridOzmen, Murat/0000-0003-4378-0839
dc.authorwosidBirhanlı, Ayşe/ABH-3226-2020
dc.authorwosidOZMEN, MURAT/A-4874-2009
dc.contributor.authorBirhanli, A
dc.contributor.authorOzmen, M
dc.date.accessioned2024-08-04T20:13:45Z
dc.date.available2024-08-04T20:13:45Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPotential developmental toxicities of six different textile dyes were evaluated using the frog embryo teratogenesis assay-Xenopus (FETAX). Xenopus laevis embryos were exposed to astrazon red FBL, astrazon blue FGRL, remazol red RR, remazol turquoise blue G-A, cibacron red FN-3G, and cibacron blue FN-R from stage 8 to 11 for a 96-h exposure period in static renewal test conditions. A minimum of 17 concentration-response tests were performed with tested dyes, excluding a control group for each dye. Median lethal concentration (LC50), malformation (EC50), non observed adverse effect concentration (NOAEC), and lowest observed adverse effect concentration (LOAEC) were calculated. Also, teratogenic index (TI), minimum concentration to inhibit growth (MCIG), and MCIG/LC50 values were determined for each of the tested dyes. Characteristic abnormalities induced by a given test material were determined by the relationship between concentration and dye in the study. Results from these studies suggested that each tested dye is teratogenic for X laevis embryos. The lowest LC50 was determined for astrazon red exposure corresponding to a value of 4.73 mg/L. The LC50 value was similar for this dye and astrazon blue; the highest TI was calculated for astrazon blue exposure. Tests with X laevis indicated that each of the tested compounds possessed teratogenic potential with varying degrees of potency: astrazon blue FGRL > remazol turquoise blue G-A > astrazon red FBL > cibacron blue FN-R > cibacron red FN-3G > remazol red RR. Different types of malformations occurred in the embryos, depending on concentration and dye. From these results, we can suggest that astrazon blue is the most toxic compound, but that the others are also highly toxic and teratogenic substances for X laevis embryos. Results of the study confirmed that the FETAX assay can be useful in an integrated biological hazard assesment for the preliminary screening of textile dye stuff.en_US
dc.identifier.doi10.1081/DCT-200039689
dc.identifier.endpage65en_US
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue1en_US
dc.identifier.pmid15720035en_US
dc.identifier.scopus2-s2.0-13244261198en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage51en_US
dc.identifier.urihttps://doi.org/10.1081/DCT-200039689
dc.identifier.urihttps://hdl.handle.net/11616/93800
dc.identifier.volume28en_US
dc.identifier.wosWOS:000226780600004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectXenopus laevisen_US
dc.subjectFETAXen_US
dc.subjecttextile dyeen_US
dc.subjecttoxicityen_US
dc.titleEvaluation of the toxicity and teratogenity of six commercial textile dyes using the frog embryo teratogenesis assay-Xenopusen_US
dc.typeArticleen_US

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