Evaluation of Transcranial Magnetic Stimulation Efficiency in Major Depressive Disorder Patients: A Magnetic Resonance Spectroscopy Study

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dc.authoridZayman, Esra Porgalı/0000-0003-1551-6782
dc.authoridUnal, Suheyla/0000-0003-3266-6256
dc.authoridERBAY, MEHMET FATİH/0000-0002-1596-3147
dc.authoriderbay, lale gönenir/0000-0002-9969-3016
dc.authoridUnal, Suheyla/0000-0003-3266-6256
dc.authorwosidZayman, Esra Porgalı/ABI-2950-2020
dc.authorwosidUnal, Suheyla/JVO-8367-2024
dc.authorwosidUnal, Suheyla/AAS-2388-2020
dc.authorwosidERBAY, MEHMET FATİH/ABI-2942-2020
dc.authorwosiderbay, lale gönenir/AAE-6285-2019
dc.authorwosidUnal, Suheyla/HJH-7559-2023
dc.contributor.authorErbay, Mehmet Fatih
dc.contributor.authorZayman, Esra Porgali
dc.contributor.authorErbay, Lale Gonenir
dc.contributor.authorUnal, Suheyla
dc.date.accessioned2024-08-04T20:46:53Z
dc.date.available2024-08-04T20:46:53Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for major depressive disorder (MDD). This study evaluated the antidepressant effect of rTMS and examined how it affected N-asetyl aspartate (NAA), choline (Cho), creatine (Cr), lactate (Lac), inyoinositol (mins), glutamate (Glu), glutathione (GSH), and glutamine (Gln) metabolite levels in the left dorsolateral prefrontal cortex (DLPFC) of MDD patients who were not receiving antidepressant medication. Methods In total, 18 patients (10 female, 8 male) were evaluated. Each patient underwent H magnetic resonance spectroscopy (H-MRS) before and within 3 days of completion of TMS therapy. All patients completed 20 sessions of rTMS directed at the left DLPFC over a 2-week period. The Hamilton Depression Scale (HAMD) scores of patients were calculated, and their responses to treatment were assessed within 1-3 days of completion of TMS. Results We found statistically significant differences in HAMD scores before and after rTMS. Moreover, the peak metabolite ratios of NAA/Cr, GSH/Cr, and Gln/Cr were significantly higher after rTMS compared to those before rTMS. Conclusion Increased understanding of the mechanism of action of TMS will improve its application and may stimulate development of new generation therapeutic agents.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Unit [921, TSA-2018-921]en_US
dc.description.sponsorshipThis project was supported by the Inonu University Scientific Research Projects Unit (project ID: 921; project code: TSA-2018-921).en_US
dc.identifier.doi10.30773/pi.2019.07.17.3
dc.identifier.endpage750en_US
dc.identifier.issn1738-3684
dc.identifier.issn1976-3026
dc.identifier.issue10en_US
dc.identifier.pmid31550877en_US
dc.identifier.scopus2-s2.0-85074105967en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage745en_US
dc.identifier.urihttps://doi.org/10.30773/pi.2019.07.17.3
dc.identifier.urihttps://hdl.handle.net/11616/99002
dc.identifier.volume16en_US
dc.identifier.wosWOS:000490558000004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Neuropsychiatric Assocen_US
dc.relation.ispartofPsychiatry Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTranscranial magnetic stimulationen_US
dc.subjectDepressionen_US
dc.subjectMagnetic resonance spectroscopyen_US
dc.subjectBrain metabolitesen_US
dc.titleEvaluation of Transcranial Magnetic Stimulation Efficiency in Major Depressive Disorder Patients: A Magnetic Resonance Spectroscopy Studyen_US
dc.typeArticleen_US

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