Salutary effects of radiopaque contrast media on the survival of random-pattern skin flaps in the rat

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dc.authorwosidBOZKURT, Mehmet/KFR-6152-2024
dc.contributor.authorAskar, I
dc.contributor.authorBozkurt, M
dc.contributor.authorOktay, MF
dc.contributor.authorGürlek, A
dc.contributor.authorKeles, C
dc.date.accessioned2024-08-04T20:13:37Z
dc.date.available2024-08-04T20:13:37Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe radiopaque contrast medium diatrizoate, has a vasodilator effect so that it is used in sudden-deafness secondary ischemic injury. However, ischemic problems are encountered, especially when longer flaps are elevated. A longer flap also has ischemic and relatively ischemic tissue, and may obtain some benefit from contrast media. Forty male Sprague-Dawley rats, weighing about 350-400 g, were used, and randomly divided into four groups (n = 10 rats each group): group 1 was the control, group 2 the diatrizoate, group 3 the iopamidol, and group 4 the iothalamate group. A rectangular 3 x 10 cm caudally based dorsal skin flap was elevated, and sutured back to its original place. In the control group, no pharmacologic agent was administered. Sodium-meglumine-diatrizoate 10 mg/kg/day was administered parenterally in the first experimental group (diatrizoate group); iopamidol 10 mg/kg/day in the second experimental group (iopamidol group); and iothalamate sodium 10 mg/kg/day in the third experimental group (iothalamate group) for 7 postoperative days. On postoperative day 7, all flaps were photographed, and the area of flap survival was measured by using a polar planimeter. The results were statistically evaluated with the Kruskal-Wallis test and Mann-Whitney U-test (P = 0.05). The mean flap survival ranged from 79% in the iopamidol group to 83% in the diatrizoate group, and was significantly greater in all experimental groups (P < 0.05) compared to the control group (59%). There was no significant difference between experimental groups (P < 0.05). We believe that radiopaque contrast media have a beneficial effect in improving skin flap viability when distal flap necrosis is a potential complication of longer flaps. (C) 2003 Wiley-Liss, Inc.en_US
dc.identifier.doi10.1002/micr.10193
dc.identifier.endpage84en_US
dc.identifier.issn0738-1085
dc.identifier.issn1098-2752
dc.identifier.issue1en_US
dc.identifier.pmid14748032en_US
dc.identifier.scopus2-s2.0-0842310841en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage81en_US
dc.identifier.urihttps://doi.org/10.1002/micr.10193
dc.identifier.urihttps://hdl.handle.net/11616/93741
dc.identifier.volume24en_US
dc.identifier.wosWOS:000188956700016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofMicrosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSudden Hearing-Lossen_US
dc.subjectSurgeryen_US
dc.titleSalutary effects of radiopaque contrast media on the survival of random-pattern skin flaps in the raten_US
dc.typeArticleen_US

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