Resveratrol attenuates inflammation and stricture formation in experimental caustic esophageal burns

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dc.authoridUĞURALP, SEMA/0000-0002-7628-0550
dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authoridIrsi, Cesim/0000-0001-6478-0382
dc.authorwosidUĞURALP, SEMA/ABH-6309-2020
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.contributor.authorUguralp, S.
dc.contributor.authorIrsi, C.
dc.contributor.authorAksoy, T.
dc.contributor.authorKarabulut, A. Bay
dc.contributor.authorKirimlioglu, H.
dc.contributor.authorMizrak, B.
dc.date.accessioned2024-08-04T20:30:57Z
dc.date.available2024-08-04T20:30:57Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe purpose of medical treatment in the caustic esophageal burns (CEB) is to decrease inflammatory reaction and to prevent stricture formation. Resveratrol has anti-inflammatory and antifibrotic properties. The aim of this study is to investigate potential therapeutic effects of resveratrol in experimental CEB. We divided 42 male Wistar albino rats into five groups: a control group, caustic groups 4 and 28 (esophageal burns were created), and resveratrol groups 4 and 28 (esophageal burns were created and resveratrol was administered). We used 25% NaOH to form CEB following the method of Gehanno and Guedon as modified by Liu and Richardson. Animals were killed on the 4th and 28th days for biochemical and histopathological examinations. We found that the mean malondialdehyde and nitric oxide assays of the caustic groups were significantly higher than that of the resveratrol groups (P < 0.05). On the other hand, glutathione assay of the resveratrol groups was significantly higher than that of the caustic groups (P < 0.05). Histologically, edema, inflammation and necrosis were found to be significantly lower in the resveratrol 4 group compared with the caustic 4 group (P < 0.05). Submucosal and muscular collagen accumulation were found significantly lower in the resveratrol 28 group compared with the caustic 28 group (P < 0.05). We conclude that resveratrol decreased both the inflammatory reaction and the stricture formation in experimental CEB.en_US
dc.identifier.doi10.1007/s00383-008-2116-x
dc.identifier.endpage430en_US
dc.identifier.issn0179-0358
dc.identifier.issn1437-9813
dc.identifier.issue4en_US
dc.identifier.pmid18283467en_US
dc.identifier.scopus2-s2.0-49649116922en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage425en_US
dc.identifier.urihttps://doi.org/10.1007/s00383-008-2116-x
dc.identifier.urihttps://hdl.handle.net/11616/94625
dc.identifier.volume24en_US
dc.identifier.wosWOS:000254238800008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Surgery Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcausticen_US
dc.subjectresveratrolen_US
dc.subjectcorrosiveen_US
dc.subjectesophagusen_US
dc.subjectinflammationen_US
dc.subjectstrictureen_US
dc.titleResveratrol attenuates inflammation and stricture formation in experimental caustic esophageal burnsen_US
dc.typeArticleen_US

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