From synthesis to biological impact of palladium bis(benzimidazol-2-ylidene) complexes: Preparation, characterization, and antimicrobial and scavenging activity

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dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authoridArfaoui, Youssef/0000-0003-1615-9502
dc.authorwosidMansour, Lamjed/AAD-8613-2019
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.authorwosidOZDEMIR, ISMAIL/KVY-3420-2024
dc.contributor.authorAmri, Nasser
dc.contributor.authorMukhrish, Yousef E.
dc.contributor.authorOzdemir, Ismail
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorArfaoui, Youssef
dc.contributor.authorMansour, Lamjed
dc.contributor.authorGatri, Rafik
dc.date.accessioned2024-08-04T20:54:57Z
dc.date.available2024-08-04T20:54:57Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPalladium-based complexes with the ligand N-heterocyclic carbene have long received attention as active catalysts for many catalytic reactions. Recently, the biological activities of these air- and moisture-stable complexes have also been investigated. In our work, bis(benzimidazol-2-ylidene)palladium complexes 3a-d were synthesized by reacting benzimidazolium salts 2a-d with PdCl2 under reflux in tetrahydrofuran for 24 h and analyzed by spectroscopy (FT-IR [Fourier transform infrared], H-1 NMR [proton nuclear magnetic resonance]) characterization, C-13 NMR [carbon-13 (C13) nuclear magnetic resonance]), and elemental analysis. The in vitro antibacterial and antifungal activities of these complexes were studied against Gram-positive and Gram-negative microorganisms, and two different fungi showed their remarkable biological potential. In addition, the analysis of the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals using spectrophotometry showed that they are an antioxidant. The potent antibacterial and antioxidant activities of the synthetic complexes suggest that they are more effective antibacterial agents. Our study extends the biological relevance of palladium bis(benzimidazol-2-ylidene) complexes with antibacterial and antioxidant activities. Furthermore, the main goal of the docking simulation is to provide a detailed analysis of the interaction between the complex and the protein of interest.en_US
dc.description.sponsorshipThe authors extended their appreciation to the Researchers Supporting Project number (RSP2023R75), King Saud University, Riyadh, Saudi Arabia. [RSP2023R75]; King Saud University, Riyadh, Saudi Arabiaen_US
dc.description.sponsorshipThe authors extended their appreciation to the Researchers Supporting Project number (RSP2023R75), King Saud University, Riyadh, Saudi Arabia.en_US
dc.identifier.doi10.1515/mgmc-2023-0007
dc.identifier.issn0792-1241
dc.identifier.issn2191-0219
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85180479532en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1515/mgmc-2023-0007
dc.identifier.urihttps://hdl.handle.net/11616/101737
dc.identifier.volume46en_US
dc.identifier.wosWOS:001108012200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDe Gruyter Poland Sp Z O Oen_US
dc.relation.ispartofMain Group Metal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectantimicrobial activityen_US
dc.subjectantioxidant activityen_US
dc.subjectbenzimidazolium saltsen_US
dc.subject2,2-diphenyl-1-picrylhydrazylen_US
dc.subjectN-heterocyclic carbene, palladiumen_US
dc.titleFrom synthesis to biological impact of palladium bis(benzimidazol-2-ylidene) complexes: Preparation, characterization, and antimicrobial and scavenging activityen_US
dc.typeArticleen_US

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