Protective effects of saffron (its active constituent, crocin) on nephropathy in streptozotocin-induced diabetic rats

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dc.authoridÖner, Zülal/0000-0003-0459-1015
dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authoridCigremis, Yilmaz/0000-0002-8600-0946
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authorwosidÖner, Zülal/T-2515-2019
dc.authorwosidAltinoz, Eyup/AAM-2378-2020
dc.authorwosidCigremis, Yilmaz/JAC-8451-2023
dc.authorwosidElbe, Hulya/D-5261-2015
dc.authorwosidCigremis, Yilmaz/O-6019-2015
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.contributor.authorAltinoz, E.
dc.contributor.authorOner, Z.
dc.contributor.authorElbe, H.
dc.contributor.authorCigremis, Y.
dc.contributor.authorTurkoz, Y.
dc.date.accessioned2024-08-04T20:40:02Z
dc.date.available2024-08-04T20:40:02Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe reactive oxygen species take role in pathogenesis of many diseases including hypoxia, hypercholesterolemia, atherosclerosis, nephropathy, hypertension, ischemia-reperfusion damage, and heart defects. The aim of this study was to evaluate whether crocin administration could protect kidney injury from oxidative stress in streptozotocin-induced diabetic rats. The rats were randomly divided into 3 groups each containing 10 animals as follows: group 1, control group; group 2, diabetes mellitus (DM) group; and group 3, DM + crocin group. At the end of the study, trunk blood was collected to determine the plasma levels of blood urea nitrogen (BUN) and creatinine (Cr). The kidney tissue was removed, and biochemical and histological changes were examined. Diabetes caused a significant increase in malondialdehyde (MDA) and xanthine oxidase (XO) activities and a decrease in glutathione (GSH) contents (p < 0.01) when compared with control group in the rat kidneys. Crocin given to DM rats significantly decreased MDA (p < 0.01) and XO (p < 0.05) activities and elevated GSH (p < 0.05) contents when compared with DM group. Plasma levels of BUN and Cr were significantly higher in the DM group when compared with the control group (p < 0.01). Pretreatment of the DM animals with crocin decreased the high level of serum Cr and BUN. Control group was normal in histological appearance, but congestion, severe inflammation, tubular desquamation, tubular necrosis, and hydropic degeneration in tubular cells were observed in the DM group. Histopathological changes markedly reduced, and appearance of kidney was nearly similar to control group in DM + crocin group. Our results show that crocin could be beneficial in reducing diabetes-induced renal injury.en_US
dc.identifier.doi10.1177/0960327114538989
dc.identifier.endpage134en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue2en_US
dc.identifier.pmid24925368en_US
dc.identifier.scopus2-s2.0-84921982992en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage127en_US
dc.identifier.urihttps://doi.org/10.1177/0960327114538989
dc.identifier.urihttps://hdl.handle.net/11616/96671
dc.identifier.volume34en_US
dc.identifier.wosWOS:000349087600002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStreptozotocinen_US
dc.subjectsaffronen_US
dc.subjectcrocinen_US
dc.subjectoxidative stressen_US
dc.subjectdiabetic nephropathyen_US
dc.titleProtective effects of saffron (its active constituent, crocin) on nephropathy in streptozotocin-induced diabetic ratsen_US
dc.typeArticleen_US

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