The palladium-based complexes bearing 1,3-dibenzylbenzimidazolium with morpholine, triphenylphosphine, and pyridine derivate ligands: synthesis, characterization, structure and enzyme inhibitions

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dc.authoridAktaş, Aydın/0000-0001-8496-6782
dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.authoridDemir, Yeliz/0000-0003-3216-1098
dc.authoridAygün, Muhittin/0000-0001-9670-9062
dc.authorwosidAktaş, Aydın/J-6194-2019
dc.authorwosidGulcin, ilhami/F-1428-2014
dc.authorwosidDemir, Yeliz/ABI-5719-2020
dc.authorwosidAygün, Muhittin/P-3605-2019
dc.contributor.authorAktas, Aydin
dc.contributor.authorYakali, Gul
dc.contributor.authorDemir, Yeliz
dc.contributor.authorGulcin, Ilhami
dc.contributor.authorAygun, Muhittin
dc.contributor.authorGok, Yetkin
dc.date.accessioned2024-08-04T20:53:02Z
dc.date.available2024-08-04T20:53:02Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe palladium-based complexes bearing N-heterocyclic carbene (NHC) ligand have long attracted attention as active catalysts for many catalytic reactions. Recently, the biological activities of these complexes, which are stable to air and moisture, have also been wondered. With the aim, we report the synthesis of a series of (NHC) Pd(Br2)(L) complexes (NHC: 1,3-dibenzylbenzimidazolium, L: morpholine, triphenylphosphine, pyridine, 3-chloropyridine, and 2-aminopyridine). All complexes were characterized by NMR (1H and 13C), FTIR spectroscopic and elemental analysis techniques. In addition, the single crystal structures of the complex 3, 4, and 6 were determined through single crystal x-ray crystallographic method. Furthermore, the carbonic anhydrase I and II isoenzymes (hCAs) and acetylcholinesterase (AChE) inhibition effects of these palladium-based complexes bearing NHC ligand were investigated. They showed highly potent inhibition effect with Ki values are between 10.06 +/- 1.49-68.56 +/- 11.53 nM for hCA I isoenzyme, 7.74 +/- 0.66 to 49.39 +/- 6.50 nM for hCA II isoenzyme and 22.83 +/- 3.21 to 64.09 +/- 9.05 nM for AChE enzyme.en_US
dc.description.sponsorshipDokuz Eylul University for the use of the Oxford Rigaku Xcalibur Eos Diffractometer [2010.KB.FEN.13]en_US
dc.description.sponsorshipThis work was supported by the Dokuz Eylul University for the use of the Oxford Rigaku Xcalibur Eos Diffractometer (purchased under University Research Grant No: 2010.KB.FEN.13).en_US
dc.identifier.doi10.1016/j.heliyon.2022.e10625
dc.identifier.issn2405-8440
dc.identifier.issue9en_US
dc.identifier.pmid36185151en_US
dc.identifier.scopus2-s2.0-85138812368en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.heliyon.2022.e10625
dc.identifier.urihttps://hdl.handle.net/11616/100914
dc.identifier.volume8en_US
dc.identifier.wosWOS:000897832400004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCell Pressen_US
dc.relation.ispartofHeliyonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectBio-catalysisen_US
dc.subjectNHCen_US
dc.subjectPalladium complexesen_US
dc.subjectPEPPSIen_US
dc.subjectSingle crystalen_US
dc.subjectCarbonic anhydrasesen_US
dc.titleThe palladium-based complexes bearing 1,3-dibenzylbenzimidazolium with morpholine, triphenylphosphine, and pyridine derivate ligands: synthesis, characterization, structure and enzyme inhibitionsen_US
dc.typeArticleen_US

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