Autoimmune hepatitis and liver transplantation: Indications, and recurrent and de novo autoimmune hepatitis

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dc.authorscopusid55396465200
dc.authorscopusid57205123244
dc.authorscopusid25959851900
dc.contributor.authorHarputluoglu M.
dc.contributor.authorCaliskan A.R.
dc.contributor.authorAkbulut S.
dc.date.accessioned2024-08-04T19:59:08Z
dc.date.available2024-08-04T19:59:08Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAutoimmune hepatitis is a chronic inflammatory disease of the liver that is characterized by circulating autoantibodies and elevated serum globulin levels. Liver transplantation may be required for patients with acute liver failure, decompensated cirrhosis, and hepatocellular carcinoma. Recurrence is defined as development of the same disease in the allograft following liver transplantation. Autoimmune hepatitis recurs in 36%-68% of the recipients 5 years after liver transplantation. De novo autoimmune hepatitis is the development of autoimmune hepatitis like clinical and laboratory characteristics in patients who had undergone liver transplantation for causes other than autoimmune hepatitis. Diagnostic work up for recurrent and de novo autoimmune hepatitis is similar to the diagnosis of the original disease, and it is usually difficult. Predniso(lo)ne with or without azathioprine is the main treatment for recurrent and de novo autoimmune hepatitis. Early diagnosis and treatment are vital for patient prognosis because de novo autoimmune hepatitis and recurrent autoimmune hepatitis cause graft loss and result in subsequent retransplantation if medical treatment fails. ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.en_US
dc.identifier.doi10.3171/2021.5.JNS21109
dc.identifier.endpage1277en_US
dc.identifier.issn0022-3085
dc.identifier.issue5en_US
dc.identifier.pmid34624863en_US
dc.identifier.scopus2-s2.0-85129950943en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1273en_US
dc.identifier.urihttps://doi.org/10.3171/2021.5.JNS21109
dc.identifier.urihttps://hdl.handle.net/11616/90424
dc.identifier.volume136en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmerican Association of Neurological Surgeonsen_US
dc.relation.ispartofJournal of Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAutoimmune hepatitisen_US
dc.subjectDe novo autoimmune hepatitisen_US
dc.subjectLiver transplantationen_US
dc.subjectRecurrence autoimmune hepatitisen_US
dc.titleAutoimmune hepatitis and liver transplantation: Indications, and recurrent and de novo autoimmune hepatitisen_US
dc.typeArticleen_US

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