The Effects of Secondhand Smoke Exposure on Postoperative Pain and Ventilation Values During One-Lung Ventilation: A Prospective Clinical Trial

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dc.authoridOzkan, Ahmet Selim/0000-0002-4543-8853
dc.authoridAkbas, Sedat/0000-0003-3055-9334
dc.authoridUçar, Muharrem/0000-0002-1232-9829
dc.authorwosidOzkan, Ahmet Selim/ABH-2918-2020
dc.authorwosidAkbas, Sedat/ABI-6053-2020
dc.authorwosidUçar, Muharrem/ABH-7761-2020
dc.contributor.authorOzkan, Ahmet Selim
dc.contributor.authorUcar, Muharrem
dc.contributor.authorAkbas, Sedat
dc.date.accessioned2024-08-04T20:45:21Z
dc.date.available2024-08-04T20:45:21Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: To investigate the relationships between secondhand smoke (SHS) exposure and oxygenation during one-lung ventilation (OLV) in lobectomy surgery and between SHS exposure and postoperative analgesic consumption. Design: Prospective study. Setting: University, Faculty of Medicine, operating room. Participants: Sixty adult patients with American Society of Anesthesiologists score II to III, aged 18 to 65 years, with a body mass index (BMI) <35 kg/m(2) scheduled for lobectomy surgery by open thoracotomy. Interventions: Patients were divided into 2 groups: the SHS group (n = 30) (urine cotinine level >= 6.0 ng/mL) and the NS (nonsmoker) group (n = 30) (urine cotinine level <6.0 ng/mL and no smoking history). SHS exposure was defined according to a previously published algorithm. Measurements and Main Results: Noninvasive blood pressure, electrocardiography, capnography, and peripheral oxygen saturation were monitored, and intra- and postoperative arterial oxygen tension (PaO2), arterial carbon dioxide tension (PaCO2), and intraoperative peak airway pressure were compared between the 2 groups. Postoperative analgesic consumption was calculated. No significant differences in demographics or preoperative data were noted between the 2 groups. PaO2 values 10 minutes after OLV onset and 10 minutes after the end of OLV were increased significantly in the NS group compared with those in the SHS group (p < 0.05). PaO2 values after 10 minutes of OLV in the NS and SHS groups were 285.5 +/- 90 mmHg and 186.7 +/- 66 mmHg, respectively. PaO2 values after OLV termination in the NS and SHS groups were 365.8 +/- 58 mmHg and 283.6 +/- 64 mmHg (p < 0.05), respectively. PaCO2 values 10 minutes after OLV onset, 10 minutes after the end of OLV, at the end of surgery, and upon arrival in the intermediate care unit were significantly different between the 2 groups (p < 0.05). Conclusion: The present study demonstrated that during OLV, patients exposed to SHS exhibited significantly lower arterial oxygen pressure compared with nonsmokers. Arterial carbon dioxide values were increased significantly in SHS-exposed patients. Morphine consumption for postoperative analgesia also was increased in patients exposed to SHS compared with that in nonsmokers. (C) 2018 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1053/j.jvca.2018.06.028
dc.identifier.endpage716en_US
dc.identifier.issn1053-0770
dc.identifier.issn1532-8422
dc.identifier.issue3en_US
dc.identifier.pmid30093188en_US
dc.identifier.scopus2-s2.0-85050978708en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage710en_US
dc.identifier.urihttps://doi.org/10.1053/j.jvca.2018.06.028
dc.identifier.urihttps://hdl.handle.net/11616/98412
dc.identifier.volume33en_US
dc.identifier.wosWOS:000460843600018en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal of Cardiothoracic and Vascular Anesthesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsecondhand smokeen_US
dc.subjectoxygenationen_US
dc.subjectone-lung ventilationen_US
dc.subjectpostoperative painen_US
dc.subjectlobectomyen_US
dc.titleThe Effects of Secondhand Smoke Exposure on Postoperative Pain and Ventilation Values During One-Lung Ventilation: A Prospective Clinical Trialen_US
dc.typeArticleen_US

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