Amelioration of streptozotocin-induced diabetic nephropathy by melatonin, quercetin, and resveratrol in rats

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dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridTaskapan, Mehmet Cagatay/0000-0002-5273-4909
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authorwosidElbe, Hulya/D-5261-2015
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidTaskapan, Mehmet Cagatay/ABI-7747-2020
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.contributor.authorElbe, H.
dc.contributor.authorVardi, N.
dc.contributor.authorEsrefoglu, M.
dc.contributor.authorAtes, B.
dc.contributor.authorYologlu, S.
dc.contributor.authorTaskapan, C.
dc.date.accessioned2024-08-04T20:39:59Z
dc.date.available2024-08-04T20:39:59Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe role of oxygen radicals are known for the pathogenesis of kidney damage. The aim of the present study was to investigate the antioxidative effects of melatonin, quercetin, and resveratrol on streptozotocin (STZ)-induced diabetic nephropathy in rats. A total of 35 male Wistar rats were divided into 5 groups as follows: control, diabetes mellitus (DM), DM + melatonin, DM + quercetin, and DM + resveratrol. All the injections started on the same day of single-dose STZ injection and continued for 30 days. At the end of this period, kidneys were removed and processed for routine histological procedures. Biochemical parameters and morphological changes were examined. In DM group, blood glucose levels were significantly increased, whereas body weights were decreased compared with the control group. Significant increases in blood urea nitrogen and tissue malondialdehyde (MDA) levels and decreases in superoxide dismutase and catalase activities were detected in DM group. Administration of melatonin, quercetin, and resveratrol significantly reduced these values. Melatonin was more efficient in reducing MDA levels than other antioxidants (p < 0.05). STZ-induced histopathological alterations including epithelial desquamation, swelling, intracytoplasmic vacuolization, brush border loss and peritubular infiltration. Additionally, basement membrane thickening and sclerotic changes were observed in glomerulus. Transforming growth factor-1 positive cells were also increased. Melatonin, quercetin, and resveratrol significantly reduced these histopathological changes. Our results indicate that melatonin, quercetin, and resveratrol might be helpful in reducing diabetes-induced renal damageen_US
dc.description.sponsorshipInonu University [2011/63]en_US
dc.description.sponsorshipThis study was financially supported by a grant from Scientific Research Fund of Inonu University (Grant number: 2011/63).en_US
dc.identifier.doi10.1177/0960327114531995
dc.identifier.endpage113en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue1en_US
dc.identifier.pmid24812155en_US
dc.identifier.scopus2-s2.0-84919667875en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage100en_US
dc.identifier.urihttps://doi.org/10.1177/0960327114531995
dc.identifier.urihttps://hdl.handle.net/11616/96639
dc.identifier.volume34en_US
dc.identifier.wosWOS:000346643700011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectStreptozotocinen_US
dc.subjectmelatoninen_US
dc.subjectquercetinen_US
dc.subjectresveratrolen_US
dc.subjectdiabetic nephropathyen_US
dc.subjectTGF-1en_US
dc.titleAmelioration of streptozotocin-induced diabetic nephropathy by melatonin, quercetin, and resveratrol in ratsen_US
dc.typeArticleen_US

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