Effects of curcumin on arginase enzyme activity, ornithine and nitric oxide levels in experimental breast cancer model

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dc.authorscopusid57741834500
dc.authorscopusid6602427108
dc.authorscopusid6602412924
dc.contributor.authorKahraman E.K.
dc.contributor.authorAydogdu N.
dc.contributor.authorErbas H.
dc.date.accessioned2024-08-04T20:02:18Z
dc.date.available2024-08-04T20:02:18Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBreast cancer accounts for almost 30% of all cancer types, making it the most common type of tumor among women in the world. Arginase, an essential enzyme of the urea cycle, leads to the formation of urea and ornithine from L-arginine using the same substrate as nitric oxide synthase (NOS). Arginase has been reported to be higher in cancer patients and can be used as a useful biomarker. In this study, we aimed to investigate the effects of curcumin, an anticarcinogenic agent, on arginase enzyme activity, ornithine, and nitric oxide (NO) levels in experimental breast cancer model in mice. 43 male Balb/c mice were used, and Erhlich acid tumor model was created in the study. Mice were divided into five groups as healthy control group, curcumin treatment before tumor formation, curcumin treatment after tumor formation and cancer control groups. 100 mg/kg curcumin were given orally. Serum and tissue arginase enzyme activities, NO levels and tissue ornithine levels were determined spectrophotometrically. Increased serum arginase activity decreased with curcumin treatment, but this difference was not statistically significant. On the other hand, decreased NO levels were increased with curcumin treatment. In tumor tissue, arginase activity and ornithine levels decreased significantly with curcumin treatment and tissue NO levels increased significantly with curcumin treatment. In our study, we show that curcumin may have a protective effect on the development of breast cancer by inhibiting arginase enzyme activity and ornithine levels, which are the precursors of polyamines, as well as inducing NO production via NOS. As a promising anticancer agent, the net effects of curcumin in this mechanism should be supported by more advanced studies and new parameters. © 2022 Ondokuz Mayis Universitesi. All rights reserved.en_US
dc.description.sponsorshipTrakya Üniversitesien_US
dc.description.sponsorshipFunding: The authors declared that this study has received financial support from Trakya University Research Project (TUBAP).en_US
dc.identifier.doi10.52142/omujecm.39.1.8
dc.identifier.endpage40en_US
dc.identifier.issn1309-4483
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85131964503en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage36en_US
dc.identifier.urihttps://doi.org/10.52142/omujecm.39.1.8
dc.identifier.urihttps://hdl.handle.net/11616/91586
dc.identifier.volume39en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherOndokuz Mayis Universitesien_US
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectarginaseen_US
dc.subjectbreast canceren_US
dc.subjectcurcuminen_US
dc.subjectnitric oxideen_US
dc.subjectornithineen_US
dc.titleEffects of curcumin on arginase enzyme activity, ornithine and nitric oxide levels in experimental breast cancer modelen_US
dc.typeArticleen_US

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