Dexpanthenol therapy reduces lung damage in a hyperoxic lung injury in neonatal rats

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dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridKaradağ, Ahmet/0000-0003-4676-683X
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidKaradağ, Ahmet/AAK-7661-2021
dc.authorwosidPolat, Alaadin/Q-4052-2018
dc.contributor.authorOzdemir, Ramazan
dc.contributor.authorDemirtas, Gulsum
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorPolat, Alaadin
dc.contributor.authorTanbag, Kevser
dc.contributor.authorTaslidere, Elif
dc.contributor.authorKaradag, Ahmet
dc.date.accessioned2024-08-04T20:41:10Z
dc.date.available2024-08-04T20:41:10Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Dexpanthenol (Dxp) plays a major role in cellular defense and in repair systems against oxidative stress and inflammatory response and it has not yet been evaluated in treatment of bronchopulmonary dysplasia (BPD). We tested the hypothesis that proposes whether Dxp decreases the severity of lung injury in an animal model of BPD.Methods: Forty rat pups were divided into four groups: control, control+Dxp, hyperoxia and hyperoxia+Dxp. All animals were processed for lung histology and tissue analysis. The degree of lung inflammation, oxidative and antioxidant capacity was assessed from lung homogenates.Results: Lung injury score and alveol diameter increased in the hyperoxia group (p<0.001). Median level of malondialdehyde, total oxidant status and oxidative stress indexes was significantly higher in the hyperoxia group compared to the other groups. The median superoxide dismutase activity in the hyperoxia group was notably less than those of control+Dxp and hyperoxia+Dxp groups (p<0.01). Similarly, lung catalase, glutathione (GSH) peroxidase and reduced GSH activities in the hyperoxia group were significantly lower than other groups. Furthermore, the hyperoxia+Dxp group had lower tumor necrosis factor- and interleukin-1 median levels compared to the hyperoxia group (p=0.007).Conclusion: Dxp treatment results in less emphysematous change as well as decrease in inflammation and oxidative stress markers in an animal model of BPD.en_US
dc.description.sponsorshipInonu University Department of Scientific Research Projectsen_US
dc.description.sponsorshipThe authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper. The authors are also grateful to Inonu University Department of Scientific Research Projects, for it was financial support.en_US
dc.identifier.doi10.3109/14767058.2015.1064104
dc.identifier.endpage1807en_US
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue11en_US
dc.identifier.pmid26135783en_US
dc.identifier.scopus2-s2.0-84940675800en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1801en_US
dc.identifier.urihttps://doi.org/10.3109/14767058.2015.1064104
dc.identifier.urihttps://hdl.handle.net/11616/96964
dc.identifier.volume29en_US
dc.identifier.wosWOS:000373515800020en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Maternal-Fetal & Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBronchopulmonary dysplasiaen_US
dc.subjectchronic lung diseaseen_US
dc.subjectdexpanthenolen_US
dc.subjecthyperoxiaen_US
dc.subjecthyperoxic lung injuryen_US
dc.subjectpantothenic aciden_US
dc.titleDexpanthenol therapy reduces lung damage in a hyperoxic lung injury in neonatal ratsen_US
dc.typeArticleen_US

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