Risk factors for acute symptomatic seizure in children with cerebral sinovenous thrombosis: Experience from a tertiary center

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dc.contributor.authorYucel, Gul
dc.contributor.authorArslan, Ahmet Kadir
dc.contributor.authorOzgor, Bilge
dc.contributor.authorSahin, Murat caglar
dc.contributor.authorOncul, Yurday
dc.contributor.authorTasolar, Sevgi Demiroz
dc.contributor.authorAkyay, Arzu
dc.date.accessioned2026-04-04T13:35:11Z
dc.date.available2026-04-04T13:35:11Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractObjective: To investigate the risk factors for acute symptomatic seizure (ASS) in children with Cerebral Sinovenous Thrombosis (CSVT) and to evaluate the effect of ASS on outcome. Methods: Cross-sectional, single-center, hospital-based retrospective analysis of 42 children with neuroimagingconfirmed CSVT recorded between December 2009 and January 2023. ASS was defined as a seizure occurring within 7 days after CSVT. Predictors for ASS were analyzed by univariate and multivariate logistic regression. Functional outcomes were evaluated using the Pediatric Stroke Outcome Measure (PSOM). Results: The average age of the 42 patients included in the study sample was 105.36 +/- 63.1 months. Almost onethird (28.6 %) of patients with CSVT developed ASS. In univariate analysis, factors associated with seizure risk were young age, low Glasgow Coma Scale at admission, long hospital stay, headache, change of consciousness, focal neurological findings, cerebral hemorrhage, motor deficit and high D-dimer level (p=0.018, p<0.001, p= 0.016, p= 0.001, p=0.014, p<0.001, p<0.001, p=0.019 and p=0.013, respectively). In multivariate analysis young age, focal neurological findings and D-dimer levels were potential predictors of ASS (p=0.004, p=0.003, p=0.036, respectively). Receiver operating characteristic (ROC) analysis for D-dimer diagnostic accuracy in patients with CSVT revealed D-dimer > 498 ng/mL (AUC=0.743). In both cohorts, PSOM scores at last follow-up were worse in those with acute seizures compared to those without (p<0.001). Conclusion: Acute seizures occurred in approximately one-third of our cohort. Young age, focal neurological findings, and high D-dimer levels are potential predictors of ASS in children. Children with ASS had worse outcomes than those without.
dc.identifier.doi10.1016/j.clineuro.2024.108571
dc.identifier.issn0303-8467
dc.identifier.issn1872-6968
dc.identifier.orcid0000-0002-9836-6814
dc.identifier.orcid0000-0003-2701-7980
dc.identifier.orcid0000-0003-3875-6770
dc.identifier.pmid39326278
dc.identifier.scopus2-s2.0-85204779492
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.clineuro.2024.108571
dc.identifier.urihttps://hdl.handle.net/11616/109677
dc.identifier.volume246
dc.identifier.wosWOS:001325015800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofClinical Neurology and Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectCerebral sinovenous thrombosis
dc.subjectAcute symptomatic seizures
dc.subjectRisk factors
dc.subjectPediatric stroke Outcome measure
dc.subjectChildren
dc.titleRisk factors for acute symptomatic seizure in children with cerebral sinovenous thrombosis: Experience from a tertiary center
dc.typeArticle

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