Effects of Melatonin and Dexamethasone on Facial Nerve Neurorrhaphy

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dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridEdizer, Deniz Tuna/0000-0003-4448-1881;
dc.authorwosidAdatepe, Nurten Uzun/AAC-1744-2020
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidUzun, Nurten/JQW-3408-2023
dc.authorwosidEdizer, Deniz Tuna/GWQ-5748-2022
dc.authorwosidEdizer, Deniz T/C-8812-2019
dc.contributor.authorEdizer, Deniz Tuna
dc.contributor.authorDonmez, Zehra
dc.contributor.authorGul, Mehmet
dc.contributor.authorYigit, Ozgur
dc.contributor.authorYigitcan, Birgul
dc.contributor.authorAdatepe, Turgut
dc.contributor.authorUzun, Nurten
dc.date.accessioned2024-08-04T20:45:56Z
dc.date.available2024-08-04T20:45:56Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description4th National Otology Neurootology Congress -- APR 21-24, 2016 -- Antalya, TURKEYen_US
dc.description.abstractOBJECTIVES: To investigate the effects of topical and systemic administrations of melatonin and dexamethasone on facial nerve regeneration. MATERIALS and METHODS: In total, 50 male albino Wistar rats underwent facial nerve axotomy and neurorrhaphy. The animals were divided into 5 groups: control, topical melatonin, systemic melatonin, topical dexamethasone, and systemic dexamethasone. Nerve conduction studies were performed preoperatively and at 3, 6, 9, and 12 weeks after drug administrations. Amplitude and latency of the compound muscle action potentials were recorded. Coapted facial nerves were investigated under light and electron microscopy. Nerve diameter, axon diameter, and myelin thickness were recorded quantitatively. RESULTS: Amplitudes decreased and latencies increased in both the melatonin and dexamethasone groups. At the final examination, the electrophysiological evidence of facial nerve degeneration was not significantly different between the groups. Histopathological examinations revealed the largest nerve diameter in the melatonin groups, followed by the dexamethasone and control groups (p<0.05). Axon diameter of the control group was smaller than those of the melatonin (topical and systemic) and topical dexamethasone groups (p<0.05). The melatonin groups had almost normal myelin ultrastructure. CONCLUSION: Electrophysiological evaluation did not reveal any potential benefit of dexamethasone and melatonin in contrast to histopathological examination, which revealed beneficial effects of melatonin in particular. These agents may increase the regeneration of facial nerves, but electrophysiological evidence of regeneration may appear later.en_US
dc.identifier.doi10.5152/iao.2018.3273
dc.identifier.endpage50en_US
dc.identifier.issn1308-7649
dc.identifier.issn2148-3817
dc.identifier.issue1en_US
dc.identifier.pmid30541731en_US
dc.identifier.scopus2-s2.0-85065596980en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage43en_US
dc.identifier.urihttps://doi.org/10.5152/iao.2018.3273
dc.identifier.urihttps://hdl.handle.net/11616/98792
dc.identifier.volume15en_US
dc.identifier.wosWOS:000465464000010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofJournal of International Advanced Otologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFacial nerveen_US
dc.subjectaxotomyen_US
dc.subjectneurorrhaphyen_US
dc.subjectcompound muscle action potentialen_US
dc.subjectregenerationen_US
dc.titleEffects of Melatonin and Dexamethasone on Facial Nerve Neurorrhaphyen_US
dc.typeConference Objecten_US

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