Mercury exposure, neopterin profile, and tryptophan degradation in dental technicians

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dc.authoridBAYDAR, Terken/0000-0002-5497-9600
dc.authoridYilmaz, Omer/0000-0002-0962-2725
dc.authoridSipahi, Hande/0000-0001-6482-3143
dc.authoridunuvar, songul/0000-0001-8454-490X
dc.authoridPalabiyik-Yucelik, Saziye Sezin/0000-0002-6239-6114
dc.authorwosidBAYDAR, Terken/JRY-1626-2023
dc.authorwosidBAYDAR, TERKEN/JAC-5447-2023
dc.authorwosidPALABIYIK, SAZIYE SEZIN/J-1537-2013
dc.authorwosidYilmaz, Omer/KHZ-8294-2024
dc.contributor.authorGirgin, Gozde
dc.contributor.authorPalabiyik-Yucelik, Saziye Sezin
dc.contributor.authorSipahi, Hande
dc.contributor.authorKilicarslan, Bilge
dc.contributor.authorUnuvar, Songul
dc.contributor.authorTutkun, Engin
dc.contributor.authorYilmaz, Omer Hinc
dc.date.accessioned2024-08-04T20:52:15Z
dc.date.available2024-08-04T20:52:15Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAmalgam has been widely used as a restorative dental material for over 150 years. Most standard dental amalgam formulations contain approximately 50% elemental mercury in a mixture of copper, tin, silver, and zinc. Mercury is a highly volatile metal, which can easily vaporize to a colorless and odorless gas. It has been demonstrated that mercury is released from dental amalgam, which is increased by chewing, eating, brushing, and drinking hot liquids. Besides this, amalgam is the main occupational exposure source of mercury for dental workers. It is known that mercury exposure causes immune modulation in humans. In this study, it was aimed to evaluate the changes in neopterin levels and tryptophan (Trp) degradation in dental technicians. It was observed that low levels of occupational mercury exposure resulted in decreased neopterin, kynurenine (Kyn), and Kyn/Trp levels. Moreover, mercury and neopterin levels had a significant positive correlation in workers. The lower neopterin levels and Kyn/Trp in dental technicians compared to an unexposed group indicates a possible immune suppression with low level of occupational mercury exposure during amalgam preparation. The relationship between urinary mercury levels as an indicator of occupational mercury exposure and neopterin reminded an effect on T-cell-mediated immune response.en_US
dc.identifier.doi10.1515/pteridines-2022-0040
dc.identifier.endpage38en_US
dc.identifier.issn0933-4807
dc.identifier.issn2195-4720
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85135925047en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage32en_US
dc.identifier.urihttps://doi.org/10.1515/pteridines-2022-0040
dc.identifier.urihttps://hdl.handle.net/11616/100843
dc.identifier.volume33en_US
dc.identifier.wosWOS:000837027300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDe Gruyter Poland Sp Z O Oen_US
dc.relation.ispartofPteridinesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectamalgamen_US
dc.subjectdentistryen_US
dc.subjectmercuryen_US
dc.subjectneopterinen_US
dc.subjectkynurenineen_US
dc.titleMercury exposure, neopterin profile, and tryptophan degradation in dental techniciansen_US
dc.typeArticleen_US

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