Effects of intraperitoneally administered folic acid on the healing of repaired tibial nerves in rats
Yükleniyor...
Dosyalar
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Journal of Reconstructive Microsurgery
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background Complete nerve regeneration and clinical healing remain a challenge
despite considerable advances in the treatment of peripheral nerve injuries. To improve
nerve regeneration, several experimental molecular procedures have been attempted.
This study aimed to investigate the effects of folic acid on peripheral nerve healing after
transection and end-to-end suture repair of the tibial nerve in rats.
Methods In this study, 20 adult male Wistar Albino rats weighing 225 to 250 g were
used. The right tibial nerves of 20 rats were explored, transected, and sutured using the
end-to-end technique. The rats were randomly allocated to either the intraperitoneally
administered folic acid group (test group) or the control group. Preoperative and
6-week postoperative neurophysiological studies were performed by the same researcher.
Myelin-sheathed axons were counted.
Results The results demonstrated that the folic acid–treated group exhibited improved
electromyographic results compared with the control group. Histological
evaluation revealed that the axons were well preserved and that the axon quantity
and density were increased in the test group compared with the control group.
Quantitative results also increased in the test group compared with the control group
(p ¼ 0.001).
Conclusion In this study, 6-week intraperitoneal administration of 80 μg/kg of folic
acid significantly improved peripheral nerve healing. Histological analysis of the group
that received folic acid revealed increased axon myelination with little granular tissue or
fibrosis. We propose that folic acid supplementation may be an effective component of
peripheral nerve injury treatment.
Açıklama
Journal of Reconstructive Microsurgery
Anahtar Kelimeler
Folic acid, Peripheral nerve, Nerve repair, Regeneration
Kaynak
Journal of Reconstructive Microsurgery
WoS Q Değeri
Scopus Q Değeri
Cilt
31
Sayı
3
Künye
A. Harma, M. Ş. Şahin, And S. Zorludemir, “Effects Of İntraperitoneally Administered Folic Acid On The Healing Of Repaired Tibial Nerves İn Rats ,” Journal Of Reconstructive Microsurgery, Vol. 31, No. 3, Pp. 191–197, Mar. 2015.
