Spread of carbapenem-resistant international clones of Acinetobacter baumannii in Turkey and Azerbaijan: a collaborative study

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dc.authoridBaran, Irmak/0000-0001-6729-948X
dc.authoridAlp Meşe, Emine/0000-0003-0189-6008
dc.authoridErsoy, Yasemin/0000-0001-5730-6682
dc.authoridDinc, Gokcen/0000-0002-9184-5003
dc.authoridYalcin, Ata/0000-0002-7243-7354
dc.authoridHosoglu, Salih/0000-0002-4034-9202
dc.authorwosidBaran, Irmak/AAV-9335-2020
dc.authorwosidHosoglu, Salih/AGH-2653-2022
dc.authorwosidAlp Meşe, Emine/AET-7752-2022
dc.authorwosidErsoy, Yasemin/AAE-4811-2020
dc.authorwosidAktas, Zerrin/L-5381-2016
dc.authorwosidDinc, Gokcen/AAK-6350-2021
dc.authorwosidMelchers, Willem/C-8819-2015
dc.contributor.authorAhmed, S. S.
dc.contributor.authorAlp, E.
dc.contributor.authorUlu-Kilic, A.
dc.contributor.authorDinc, G.
dc.contributor.authorAktas, Z.
dc.contributor.authorAda, B.
dc.contributor.authorBagirova, F.
dc.date.accessioned2024-08-04T20:42:35Z
dc.date.available2024-08-04T20:42:35Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractEpidemic clones of Acinetobacter baumannii, described as European clones I, II, and III, are associated with hospital epidemics throughout the world. We aimed to determine the molecular characteristics and genetic diversity between European clones I, II, and III from Turkey and Azerbaijan. In this study, a total of 112 bloodstream isolates of carbapenem-resistant Acinetobacter spp. were collected from 11 hospitals across Turkey and Azerbaijan. The identification of Acinetobacter spp. using conventional and sensitivity tests was performed by standard criteria. Multiplex polymerase chain reaction (PCR) was used to detect OXA carbapenemase-encoding genes (bla(OXA-23-like), bla(OXA-24-like), bla(OXA-51-like), and bla(OXA-58-like)). Pulsed-field gel electrophoresis (PFGE) typing was used to investigate genetic diversity. The bla(OXA-51-like) gene was present in all 112 isolates, 75 (67 %) carried bla(OXA-23-like), 7 (6.2 %) carried bla(OXA-58-like) genes, and 5 (4.5 %) carried bla(OXA-24-like) genes. With a 90 % similarity cut-off value, 15 clones and eight unique isolates were identified. The largest clone was cluster D, with six subtypes. Isolates from clusters D and I were widely spread in seven different geographical regions throughout Turkey. However, F cluster was found in the northern and eastern regions of Turkey. EU clone I was grouped within J cluster with three isolates found in Antalya, Istanbul, and Erzurum. EU clone II was grouped in the U cluster with 15 isolates and found in Kayseri and Diyarbakir. The bla(OXA-24-like) gene in carbapenemases was identified rarely in Turkey and has been reported for the first time from Azerbaijan. Furthermore, this is the first multicenter study in Turkey and Azerbaijan to identify several major clusters belonging to European clones I and II of A. baumannii.en_US
dc.description.sponsorshipErciyes University Scientific Research Projects [BAP kodu 4059]en_US
dc.description.sponsorshipThis study was supported by Erciyes University Scientific Research Projects (BAP kodu 4059).en_US
dc.identifier.doi10.1007/s10096-016-2685-x
dc.identifier.endpage1468en_US
dc.identifier.issn0934-9723
dc.identifier.issn1435-4373
dc.identifier.issue9en_US
dc.identifier.pmid27259712en_US
dc.identifier.scopus2-s2.0-84982267557en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1463en_US
dc.identifier.urihttps://doi.org/10.1007/s10096-016-2685-x
dc.identifier.urihttps://hdl.handle.net/11616/97464
dc.identifier.volume35en_US
dc.identifier.wosWOS:000385857700013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal of Clinical Microbiology & Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOxa-23 Beta-Lactamaseen_US
dc.subjectSyrian Refugeesen_US
dc.subjectOutbreaken_US
dc.subjectCareen_US
dc.subjectInfectionsen_US
dc.subjectIdentificationen_US
dc.subjectHospitalsen_US
dc.subjectKoreaen_US
dc.titleSpread of carbapenem-resistant international clones of Acinetobacter baumannii in Turkey and Azerbaijan: a collaborative studyen_US
dc.typeArticleen_US

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