House dust-mites: Effect on antioxidant enzyme activities

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dc.authorscopusid34770872600
dc.authorscopusid22978273500
dc.authorscopusid13611422300
dc.authorscopusid7006065727
dc.authorscopusid7003339054
dc.authorscopusid6603798076
dc.authorscopusid22979099500
dc.contributor.authorKarabulut A.B.
dc.contributor.authorAtambay M.
dc.contributor.authorKaraman U.
dc.contributor.authorKilic E.
dc.contributor.authorYazar S.
dc.contributor.authorSaraymen R.
dc.contributor.authorDaldal N.
dc.date.accessioned2024-08-04T20:00:52Z
dc.date.available2024-08-04T20:00:52Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: House dust-mites are potent allergens of the indoor environment and are common inhabitants of houses worldwide. Free radicals are constantly produced by cells, mostly as reactive oxygen species. Once produced, free radicals are removed by antioxidant defenses, including the enzymes SOD, GPx, and CAT. Material/Methods: The aim was to describe the importance of the antioxidant enzymes SOD, GPx, and CAT co-acting in human cells against toxic reactive oxygen species and their relationship with pathophysiological processes in subjects who have dust-mites in their homes. Results: The activities of erythrocyte GPx and SOD in skin-test-positive (dust-mite-positive/negative) patients were significantly lower than those in dust-mite- and skin-test-negative controls (p<0.05). Among the skin-test-positive patients, SOD activity was found to be lower in dust-mite-positive than in dust-mite-negative patients (p<0.05). There was not a statistically significant difference between the CAT levels of skin-test-positive (dust-mite-positive/negative) patients and dust-mite- and skin-test-negative controls (p>0.05). Conclusions: This study clearly shows that dust-mite depresses the activities of SOD, GPx, and, to a small extent, CAT, which influence cellular reducing capacity and consequently may increase asthma risk more than other allergens. © Med Sci Monit, 2006.en_US
dc.identifier.endpageCR381en_US
dc.identifier.issn1234-1010
dc.identifier.issue9en_US
dc.identifier.pmid16940931en_US
dc.identifier.scopus2-s2.0-33748552352en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageCR378en_US
dc.identifier.urihttps://hdl.handle.net/11616/91053
dc.identifier.volume12en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofMedical Science Monitoren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllergyen_US
dc.subjectCatalaseen_US
dc.subjectDust-miteen_US
dc.subjectGlutathione peroxidaseen_US
dc.subjectSuperoxide dismutaseen_US
dc.titleHouse dust-mites: Effect on antioxidant enzyme activitiesen_US
dc.typeArticleen_US

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