Protective Effect of Nerolidol on Paclitaxel-Induced Reproductive Toxicity in Rats: Oxidative Stress and Inflammation

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dc.contributor.authorAyhan, Idris
dc.contributor.authorTurkmen, Nese Basak
dc.contributor.authorTaslidere, Asli
dc.contributor.authorAydin, Muhterem
dc.contributor.authorCiftci, Osman
dc.date.accessioned2026-04-04T13:33:23Z
dc.date.available2026-04-04T13:33:23Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractPaclitaxel (PAC), derived from Taxus brevifolia, is used to treat solid tumours but causes reproductive toxicity due to oxidative stress, affecting sperm quality and testicular tissue. Nerolidol (NRL), an antioxidant sesquiterpene alcohol, has not been studied for its potential to reduce PAC-induced reproductive damage. This study investigates NRL's ability to mitigate PAC-induced reproductive toxicity in rats. Forty healthy adult male Spraque Dawley rats were randomly divided into four equal groups (Control, PAC, NRL, PAC + NRL). PAC was given intraperitoneally at a dose of 2 mg/kg once a week for 4 weeks. NRL was given orally at a dose of 100 mg/kg/day for 4 weeks. Control group received PAC and NRL vehicles. After 4 weeks, testis tissue samples were collected, and parameters, including oxidants, antioxidants, sperm motility, density, abnormal spermatozoon ratios and cytokines, were measured. PAC administration increased oxidant levels and decreased antioxidant enzyme activities. Nerolidol mitigated these alterations significantly. Similarly, PAC elevated IL-1, IL-6, TNF-alpha levels and lowered IL-10 levels, these effects attenuated by nerolidol in the PAC + NRL group. In conclusion, it was determined that PAC induces reproductive toxicity through oxidative stress, and NRL demonstrates potential in ameliorating these effects through its antioxidant activity.
dc.identifier.doi10.1111/bcpt.14126
dc.identifier.issn1742-7835
dc.identifier.issn1742-7843
dc.identifier.issue2
dc.identifier.orcid0000-0003-3902-3210
dc.identifier.orcid0000-0003-4625-7218
dc.identifier.orcid0000-0001-5755-3560
dc.identifier.pmid39815991
dc.identifier.scopus2-s2.0-85214922026
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1111/bcpt.14126
dc.identifier.urihttps://hdl.handle.net/11616/109113
dc.identifier.volume136
dc.identifier.wosWOS:001396483000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofBasic & Clinical Pharmacology & Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectantioxidant
dc.subjectnerolidol
dc.subjectoxidative stress
dc.subjectpaclitaxel
dc.subjectreproductive toxicity
dc.titleProtective Effect of Nerolidol on Paclitaxel-Induced Reproductive Toxicity in Rats: Oxidative Stress and Inflammation
dc.typeArticle

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