Evaluation of the effects of novel nafimidone derivatives on thermal hypoalgesia in mice with diabetic neuropathy

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dc.contributor.authorKamışlı, Suat
dc.contributor.authorKarakurt, Arzu
dc.contributor.authorUyumlu, Ayşe B.
dc.contributor.authorSatılmış, Basri
dc.contributor.authorAlagöz, Abdullah
dc.contributor.authorGenç, Metin F.
dc.contributor.authorBatcıoğlu, Kadir
dc.date.accessioned2020-05-01T18:10:30Z
dc.date.available2020-05-01T18:10:30Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractÖz (İngilizce): Objective: Diabetic neuropathy (DN) is a common complication in Diabetes Mellitus. The streptozotocin-induced diabetic rodent is the most commonly used animal model of diabetes and increased sodium channel expression and activity were revealed in this model. At this study, we evaluated the effect of three different nafimidone derivatives which have possible anticonvulsant activity on disorders of thermal pain sensation in diabetic mice. Study Design: Randomized animal experiment. Material and Methods: Mice were divided randomly into five groups (5 mice per group): Control, Diabetes, Dibetes+C1, Diabetes+C2, Diabetes+C3. We used hot and cold plate, and tail-immersion tests for assessment of thermal nociceptive responses. Results: Compared with the control group, the hot-plate response time and the number of paw liftings on cold plate as important indicators of loss of sensation increased, but no significant difference (p>0.05) was found in tail-immersion response time test in diabetes group. C3 compound moved it back to control group levels in the all of three tests. C1 and C2 compounds were effective only in cold-plate test. Conclusion: Nafimidone derivatives may be effective in the cases where epilepsy and diabetes occur together since it has shown efficacy against loss of sensation which evolves in diabetic neuropathy over time as well as its antiepileptic effect.en_US
dc.identifier.citationSuat K., Arzu K., Ayşe B. U., Basri S., Abdullah A., Metin F. G., Kadir B. (2013). Evaluation of the effects of novel nafimidone derivatives on thermal hypoalgesia in mice with diabetic neuropathy , Balkan Medical Journal,en_US
dc.identifier.endpage98en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue1en_US
dc.identifier.pmid25207077en_US
dc.identifier.startpage94en_US
dc.identifier.trdizinid168158en_US
dc.identifier.urihttps://hdl.handle.net/11616/15430
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/168158
dc.identifier.volume30en_US
dc.identifier.wosWOS:000317543300021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherBalkan Medical Journalen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.titleEvaluation of the effects of novel nafimidone derivatives on thermal hypoalgesia in mice with diabetic neuropathyen_US
dc.typeArticleen_US

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