Serum Nickel and Titanium Levels after Transcatheter Closure of Atrial Septal Defects with Amplatzer Septal Occluder

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dc.authoridTaskapan, Mehmet Cagatay/0000-0002-5273-4909
dc.authoridKARAKURT, CEMŞIT/0000-0002-9246-8107
dc.authoridELKIRAN, OZLEM/0000-0002-6855-0346
dc.authorwosidTaskapan, Mehmet Cagatay/ABI-7747-2020
dc.authorwosidKARAKURT, CEMŞIT/ABE-2330-2020
dc.authorwosidelkiran, ozlem/ABI-8212-2020
dc.authorwosidELKIRAN, OZLEM/AAG-2241-2020
dc.contributor.authorElkiran, Ozlem
dc.contributor.authorKarakurt, Cemsit
dc.contributor.authorKocak, Gulendam
dc.contributor.authorTaskapan, Cagatay
dc.date.accessioned2024-08-04T20:45:41Z
dc.date.available2024-08-04T20:45:41Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction. There is a concern about release of nickel and titanium after implantation of nitinol-containing devices. Objective. To evaluate serum nickel and titanium release after implantation of Amplatzer occluder. Materials and methods. In 38 pediatric patients with no history of nickel sensitivity, blood samples were drawn 24 hours before and 24 hours, 1, 3, 6, and 12 months after implantation. Nickel and titanium concentrations were measured by atomic absorption spectrophotometry. Results. The median serum nickel level which was 0.44ng/mL before the implantation increased to 1.01ng/mL 24 hours after implantation and 1.72ng/mL one month after implantation. The maximum level was detected 3 months after implantation, with a median level of 1.96ng/mL. During follow-up, the nickel levels decreased to those measured before implantation. Serum nickel levels at the 24th hour, 1st month, and 3rd month following implantation were found to have increased significantly. No patients showed a detectable serum titanium level. Discussion. This is the first study that evaluated both serum nickel and titanium release after implantation of the Amplatzer occluder. Our study shows that nickel is released from the device in the first few months after implantation. Therefore, in patients with nickel allergy, other devices may be considered.en_US
dc.identifier.doi10.1155/2019/7891746
dc.identifier.issn2090-8016
dc.identifier.issn2090-0597
dc.identifier.pmid30719342en_US
dc.identifier.scopus2-s2.0-85060109879en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1155/2019/7891746
dc.identifier.urihttps://hdl.handle.net/11616/98613
dc.identifier.volume2019en_US
dc.identifier.wosWOS:000455733300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofCardiology Research and Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTotal Hip-Arthroplastyen_US
dc.subjectNiti Shape-Memoryen_US
dc.subjectSurgical Closureen_US
dc.subjectSurface-Treatmenten_US
dc.subjectFollow-Upen_US
dc.subjectDeviceen_US
dc.subjectBiocompatibilityen_US
dc.subjectChildrenen_US
dc.subjectReleaseen_US
dc.subjectGenotoxicityen_US
dc.titleSerum Nickel and Titanium Levels after Transcatheter Closure of Atrial Septal Defects with Amplatzer Septal Occluderen_US
dc.typeArticleen_US

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