The effects of methylprednisolone and halofuginone on preventing esophageal and hypopharyngeal fibrosis in delivered radiotherapy

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dc.authoridYALCIN, SINASI/0000-0002-6528-9234
dc.authoridKeleş, Erol/0000-0003-4443-6714
dc.authoridAKPOLAT, Nusret/0000-0002-9138-2117
dc.authoridKaygusuz, İrfan/0000-0002-5237-2362
dc.authoridKARLIDAG, turgut/0000-0003-2748-7309
dc.authorwosidYALCIN, SINASI/W-7128-2018
dc.authorwosidKeleş, Erol/W-7207-2018
dc.authorwosidAKPOLAT, Nusret/ABF-6986-2020
dc.authorwosidKaygusuz, İrfan/W-1486-2018
dc.authorwosidKARLIDAG, turgut/W-7266-2018
dc.contributor.authorDabak, Hakan
dc.contributor.authorKarlidag, Turgut
dc.contributor.authorAkpolat, Nusret
dc.contributor.authorKeles, Erol
dc.contributor.authorAlpay, Hayrettin Cengiz
dc.contributor.authorSerin, Meltem
dc.contributor.authorKaygusuz, Irfan
dc.date.accessioned2024-08-04T20:32:31Z
dc.date.available2024-08-04T20:32:31Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, we assessed the effects of halofuginone and methylprednisolone on hypopharyngeal and esophageal stricture that can develop following radiation to the head and neck of rats. Rats were divided into four groups randomly and 18 Gy radiation was given to the head and neck regions of all rats except the control group. Group 1 (Control Group): No radiation or drugs were administered. Group 2 (Radiation Group): only radiation was applied without any drugs. Group 3 (Halofuginone Group): halofuginone 100 mu g/kg per day was given intraperitoneally. Group 4 (Methylprednisolone Group): methylprednisolone 1 mg/kg per day was administered intramuscularly. In all groups, 90 days after application of radiation, sections of the proximal esophagus and hypopharynx were examined for fibrosis, fibroblast proliferation, vascularization, epithelial atypia, necrosis, polymorphonuclear leukocytes, mononuclear cells, and stenosis index by light microscope and the hydroxyproline levels were assessed biochemically. Fibrosis, epithelial atypia and hydroxyproline levels were found to be significantly higher in the radiation group compared to the control group (P < 0.05). We did not observe fibrosis in either the halofuginone or the control groups. Fibrosis was also significantly lower in the methylprednisolone group than the radiation group (P < 0.05). The differences of the stenosis index scores between the groups were not statistically significant (P < 0.05). Vascularization was similar in all groups. We think that especially halofuginone is a drug that can be used safely to prevent fibrosis due to radiotherapy, but further studies are needed.en_US
dc.identifier.doi10.1007/s00405-010-1242-y
dc.identifier.endpage1435en_US
dc.identifier.issn0937-4477
dc.identifier.issue9en_US
dc.identifier.pmid20364346en_US
dc.identifier.scopus2-s2.0-77955518874en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1429en_US
dc.identifier.urihttps://doi.org/10.1007/s00405-010-1242-y
dc.identifier.urihttps://hdl.handle.net/11616/95102
dc.identifier.volume267en_US
dc.identifier.wosWOS:000280223700017en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Archives of Oto-Rhino-Laryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRadiationen_US
dc.subjectEsophagusen_US
dc.subjectHalofuginoneen_US
dc.subjectFibrosisen_US
dc.subjectHydroxyprolineen_US
dc.titleThe effects of methylprednisolone and halofuginone on preventing esophageal and hypopharyngeal fibrosis in delivered radiotherapyen_US
dc.typeArticleen_US

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