Beta-glucan effects on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxicity in liver and brain

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dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authorwosidbasak, nese/ABH-5495-2020
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.contributor.authorTurkmen, Nese Basak
dc.contributor.authorOzek, Dilan Askin
dc.contributor.authorTaslidere, Asli
dc.contributor.authorDogan, Fatih
dc.contributor.authorCiftci, Osman
dc.date.accessioned2024-08-04T20:51:37Z
dc.date.available2024-08-04T20:51:37Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstract2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a common environmental contaminant that is toxic to brain, heart, kidney and liver. TCDD toxicity is due to free radical formation. Beta-glucan is an antioxidant that exhibits beneficial effects on health. We investigated the effects of beta-glucan on brain and liver tissues of rats with TCDD induced toxicity. We used female rats divided into four groups: control, TCDD group treated with TCDD 2 mu g/kg/week, beta-glucan group treated with 50 mg/kg/day beta-glucan for 3 weeks, TCDD + beta-glucan group treated with 2 mu g/kg/week TCDD and 50 mg/kg/day beta-glucan together for 3 weeks. We found that the thiobarbituric acid reactive substance (TBARS) levels were increased significantly in the TCDD group compared to the other groups. Glutathione (GSH) levels, and superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities were reduced in the TCDD group compared to the control group. SOD, CAT, GPx activities and GSH levels were increased in the TCDD + beta-glucan group. Histopathological observations were consistent with our biochemical findings. The oxidative stress and histopathology caused by TCDD were ameliorated by beta-glucan treatment. Beta-glucan should be explored for preventing brain and liver damage caused by TCDD toxicity.en_US
dc.identifier.doi10.1080/10520295.2022.2025902
dc.identifier.endpage448en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue6en_US
dc.identifier.pmid35073792en_US
dc.identifier.scopus2-s2.0-85123825477en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage441en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2022.2025902
dc.identifier.urihttps://hdl.handle.net/11616/100448
dc.identifier.volume97en_US
dc.identifier.wosWOS:000746810300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBeta-glucanen_US
dc.subjectbrain damageen_US
dc.subjectliver damageen_US
dc.subjectoxidative stressen_US
dc.subjectratsen_US
dc.subject2en_US
dc.subject3en_US
dc.subject7en_US
dc.subject8-tetrachlorodibenzo-p-dioxin (TCDD)en_US
dc.titleBeta-glucan effects on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxicity in liver and brainen_US
dc.typeArticleen_US

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