Effects of Peripheral Administration of Kisspeptin on Pubertal Maturation and Serum Leptin Levels in Female Rats

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridYilmaz, Bayram/0000-0002-2674-6535
dc.authoridOzcan, Mete/0000-0002-5551-4880
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidAYAR, Ahmet/I-1379-2014
dc.authorwosidYilmaz, Bayram/IXD-3395-2023
dc.authorwosidKelestimur, Haluk/V-9392-2018
dc.authorwosidOzcan, Mete/V-8758-2018
dc.contributor.authorAlcin, Ergul
dc.contributor.authorOzcan, Mete
dc.contributor.authorAyar, Ahmet
dc.contributor.authorYilmaz, Bayram
dc.contributor.authorTurkoz, Yusuf
dc.contributor.authorKelestimur, Haluk
dc.date.accessioned2024-08-04T20:35:37Z
dc.date.available2024-08-04T20:35:37Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to investigate the effects of exogenous kisspeptin on pubertal maturation in immature female rats. Material and Methods: Wistar female rats were weaned when they were 21 days old. The rats were divided into two groups. Controls (n=10) received saline only (1 ml/kg). Experimental rats (n=9) were intraperitoneally injected with daily 100 nmol kisspeptin-10 between 09.00h-10.00h a.m. starting from the day 26. Body weight and food intake were daily determined, and vaginal opening (VO) was daily monitored starting from day 26. The animals were decapitated when the first diestrus was determined by vaginal smears. Upon decapitation, serum was separated and stored at -20 degrees C until measurement of leptin, luteinizing hormone (LH) and estradiol. Uterus and ovaries were dissected out and weighed. Results: Intraperitoneal injection of 100 nmol kisspeptin-10 did not change median VO ages. There were no differences in food intake, and percentages of body weight change, between control and kisspeptin groups during the experimental period. Kisspeptin administration elicited significant (P<0.01) increases in uterus weight over control values. Serum leptin levels were significantly lower (P<0.05) in kisspeptin-treated group compared to vehicle group. Kisspeptin administration increased (P<0.05) serum LH and estradiol levels. Conclusion: Chronic peripheral administration of kisspeptin-10 does not advance puberty onset as estimated from the date of vaginal opening, but potentiates other conventional indices of maturation of reproductive axis such as elevated uterine weight and increased serum levels of LH and estradiol.en_US
dc.description.sponsorshipTUBITAK [107T825]en_US
dc.description.sponsorshipThis work was supported by a grant from TUBITAK (Project No. 107T825).en_US
dc.identifier.doi10.5336/medsci.2010-21945
dc.identifier.endpage1483en_US
dc.identifier.issn1300-0292
dc.identifier.issn2146-9040
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-80855129584en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1477en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2010-21945
dc.identifier.urihttps://hdl.handle.net/11616/95483
dc.identifier.volume31en_US
dc.identifier.wosWOS:000298720200023en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherOrtadogu Ad Pres & Publ Coen_US
dc.relation.ispartofTurkiye Klinikleri Tip Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPubertyen_US
dc.subjectkisspeptin-10en_US
dc.subjectleptinen_US
dc.titleEffects of Peripheral Administration of Kisspeptin on Pubertal Maturation and Serum Leptin Levels in Female Ratsen_US
dc.typeArticleen_US

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