Relationship between guanosine triphosphate pathway and tetrahydrobiopterin in gestational diabetes mellitus

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dc.authoridMELEKOGLU, RAUF/0000-0001-7113-6691
dc.authoridSalva, Emine/0000-0002-1159-5850
dc.authoridŞALVA, EMINE/0000-0002-1159-5850
dc.authoridÜnüvar, Songül/0000-0001-8454-490X
dc.authoridAcar, Ceren/0000-0003-1842-9203
dc.authorwosidYaşar, Şeyma/ABI-8055-2020
dc.authorwosidMELEKOGLU, RAUF/AAF-1614-2019
dc.authorwosidSalva, Emine/ABI-2766-2020
dc.authorwosidŞALVA, EMINE/CAH-3062-2022
dc.authorwosidÜnüvar, Songül/ABH-5516-2020
dc.authorwosidAcar, Ceren/M-2926-2019
dc.contributor.authorUnuvar, Songul
dc.contributor.authorMelekoglu, Rauf
dc.contributor.authorSalva, Emine
dc.contributor.authorAcar, Ceren
dc.contributor.authorYasar, Seyma
dc.date.accessioned2024-08-04T20:48:59Z
dc.date.available2024-08-04T20:48:59Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose The present study assesses the change in tetrahydrobiopterin (BH4), one of the most important products in the guanosine triphosphate (GTP) pathway and in other parameters that might affect nitric oxide (NO) production, in gestational diabetes mellitus (GDM). Methods The study included 100 healthy pregnant women and 100 women diagnosed with GDM. Serum levels of neopterin, BH4 and NO were measured. The levels of endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS) and guanosine triphosphate cyclohydrolase I (GCHI/GTPCH) gene expression were determined. Results It was found that diabetes led to an increase in neopterin and NO levels, and a decrease in BH4 levels. A stimulation was observed in eNOS gene expression in the GDM group when compared to the control group, while GCHI levels were found to decrease when compared to the control group. iNOS gene expression was detected in neither the healthy controls nor the patient group. Conclusions Decreased NO bioavailability plays an important role in the progression of such macrovascular diseases as diabetes. BH4 levels decrease in diabetes patients, while the increased gene expression of GCHI reverses the diabetes-related BH4 deficiency and allows the endothelial cells to regain their ability to produce NO. Since GCHI is the rate-limiting enzyme in the biosynthesis of BH4, changes in GCHI levels directly affect the BH4 levels and the NO metabolism, leading to an increased risk of macrovascular complications. The significant increase in neopterin levels suggest that this is a potential biomarker for the early diagnosis of GDM.en_US
dc.description.sponsorshipInonu University Department of Scientific Research Projects [TSA-2018-1103]en_US
dc.description.sponsorshipThis study was supported by Inonu University Department of Scientific Research Projects (Project number: TSA-2018-1103).en_US
dc.identifier.doi10.1007/s40200-020-00659-1
dc.identifier.endpage1396en_US
dc.identifier.issn2251-6581
dc.identifier.issue2en_US
dc.identifier.pmid33520842en_US
dc.identifier.scopus2-s2.0-85092459359en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1391en_US
dc.identifier.urihttps://doi.org/10.1007/s40200-020-00659-1
dc.identifier.urihttps://hdl.handle.net/11616/99582
dc.identifier.volume19en_US
dc.identifier.wosWOS:000581748300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Int Publ Agen_US
dc.relation.ispartofJournal of Diabetes and Metabolic Disordersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNeopterinen_US
dc.subjectGestational Diabetes Mellitusen_US
dc.subjectGuanosine Triphosphate Pathwayen_US
dc.subjectTetrahydrobiopterinen_US
dc.titleRelationship between guanosine triphosphate pathway and tetrahydrobiopterin in gestational diabetes mellitusen_US
dc.typeArticleen_US

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