Synthesis, structural and thermal characterizations, dielectric properties and in vitro cytotoxic activities of new 2,2,4,4-tetra(4'-oxy-substituted-chalcone)-6,6-diphenylcyclotriphosphazene derivatives

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dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridBiryan, Fatih/0000-0001-9198-3329
dc.authoridKORAN, KENAN/0000-0002-2218-7211
dc.authoridTekin, Çiğdem/0000-0001-9038-1924
dc.authoridGORGULU, AHMET/0000-0002-7549-1524
dc.authoridGorgulu, Ahmet Orhan/0000-0003-0632-4834
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidGörgülü, Ahmet Orhan/AAQ-4282-2021
dc.authorwosidGörgülü, Ahmet Orhan/W-1964-2018
dc.authorwosidBiryan, Fatih/ABH-3269-2020
dc.authorwosidKORAN, KENAN/L-6764-2016
dc.authorwosidBiryan, Fatih/W-7005-2018
dc.contributor.authorKoran, Kenan
dc.contributor.authorTekin, Cigdem
dc.contributor.authorBiryan, Fatih
dc.contributor.authorTekin, Suat
dc.contributor.authorSandal, Suleyman
dc.contributor.authorGorgulu, Ahmet Orhan
dc.date.accessioned2024-08-04T20:43:00Z
dc.date.available2024-08-04T20:43:00Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, we aimed to investigate the relationship between the cytotoxic and dielectric properties of newly synthesized 2,2,4,4-tetra(4'-oxy-substituted-chalcone)-6,6-diphenylcyclotriphosphazene derivatives (3-10). Firstly, 2,2,4,4-tetrachloro-6,6-diphenyl cyclotriphosphazene (2) was obtained through Friedel Crafts alkylation in the presence of hexachlorocyclotriphosphazene, benzene and triethylamine and anhydrous AlCl3. The compounds 3-10 were synthesized from the reaction of the hydroxychalcone compounds (1a-h) with 2 in the presence of K2CO3 and within the acetone solvent for the first time and their dielectric constant, dielectric loss factor and ac conductivity of compounds 3-10 were examined through the impedance analyzer as a function of frequency. The in vitro cytotoxic activities of compounds 3-10 in five different concentrations (1, 5, 25, 50, and 100 mu M) were analyzed by colorimetric MTT assay which is based on reduction of MTT salt by mitochondria of alive cells over the human ovarian cancer (A2780) and human prostate cancer (PC-3 and LNCaP) cell lines. The LogIC(50) values of 3-10 were calculated by using a Graphpad prism 6 programs on a computer. The obtained results suggests that the compounds have a powerful cytotoxic activity (especially A2780, p < 0.05).en_US
dc.description.sponsorshipScientific & Technological Research Council of Turkey (TUBITAK) [115Z101]en_US
dc.description.sponsorshipThis work was supported financially by The Scientific & Technological Research Council of Turkey (TUBITAK) (Project Number: 115Z101).en_US
dc.identifier.doi10.1007/s00044-017-1810-4
dc.identifier.endpage974en_US
dc.identifier.issn1054-2523
dc.identifier.issn1554-8120
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85013993661en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage962en_US
dc.identifier.urihttps://doi.org/10.1007/s00044-017-1810-4
dc.identifier.urihttps://hdl.handle.net/11616/97709
dc.identifier.volume26en_US
dc.identifier.wosWOS:000399237300009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Birkhauseren_US
dc.relation.ispartofMedicinal Chemistry Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChalcone-cyclotriphosphazeneen_US
dc.subjectCancer cell linesen_US
dc.subjectDielectric propertyen_US
dc.subjectCytotoxic activityen_US
dc.subjectDielectric constanten_US
dc.titleSynthesis, structural and thermal characterizations, dielectric properties and in vitro cytotoxic activities of new 2,2,4,4-tetra(4'-oxy-substituted-chalcone)-6,6-diphenylcyclotriphosphazene derivativesen_US
dc.typeArticleen_US

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