In vitro evaluation of long-term cytotoxic response of injection-molded polyamide and polymethyle metacrylate denture base materials on primary fibroblast cell culture

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dc.authoridHacimuftuoglu, Ahmet/0000-0002-9658-3313
dc.authoridBAYINDIR, FUNDA/0000-0001-5699-2879
dc.authorwosidtatar, abdulgani/I-6300-2012
dc.authorwosidHacimuftuoglu, Ahmet/U-9109-2018
dc.contributor.authorUzun, Ismail Hakki
dc.contributor.authorTatar, Abdulgani
dc.contributor.authorHacimuftuoglu, Ahmet
dc.contributor.authorSaruhan, Fatih
dc.contributor.authorBayindir, Funda
dc.date.accessioned2024-08-04T20:37:51Z
dc.date.available2024-08-04T20:37:51Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective. This study investigated the long-term cytotoxic response of thermoplastic polyamide and conventional polymethyle metacrylate (PMMA) denture base materials. Materials and ethods. Twenty discs were prepared for each polyamide, heat and cold cured PMMA denture base resins (totally 60) and divided into four sub-groups (n = 5). Cytotoxicity was assessed with the direct cell contact method using cell viability and neutral red (NR) uptake assay. Each sub-group was tested at initial and after being aged for 24 h, 1 week and 8 weeks with artificial saliva according to ISO 10993 standards. Results. There were no significantly difference among the materials and control groups after initial, 24 h and 1 week testing. In 24 h testing, only Deflex was more toxic according to the Control group (p < 0.05). After 8 weeks of aging with artificial saliva, all materials were significantly cytotoxic when compared to the control group. QC20 was more toxic than Deflex and SC Cold Cure (p < 0.05). There were significant differences between the 8 week aging group and the initial, 24 h and 1 week testing for all materials (p < 0.05). Conclusions. Cytotoxicity of all tested denture base materials increased significantly after the long-term aging. Therefore, long-term aging may be useful to determine a dental material's toxicity. Polyamide denture base material had a similar toxicity profile with conventional heat-and cold-cured PMMA.en_US
dc.identifier.doi10.3109/00016357.2012.757648
dc.identifier.endpage1272en_US
dc.identifier.issn0001-6357
dc.identifier.issue5en_US
dc.identifier.pmid23998515en_US
dc.identifier.scopus2-s2.0-84883574550en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1267en_US
dc.identifier.urihttps://doi.org/10.3109/00016357.2012.757648
dc.identifier.urihttps://hdl.handle.net/11616/96196
dc.identifier.volume71en_US
dc.identifier.wosWOS:000324258100037en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofActa Odontologica Scandinavicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdenture base materialsen_US
dc.subjectcytotoxicityen_US
dc.subjectlong-term agingen_US
dc.subjectcell cultureen_US
dc.titleIn vitro evaluation of long-term cytotoxic response of injection-molded polyamide and polymethyle metacrylate denture base materials on primary fibroblast cell cultureen_US
dc.typeArticleen_US

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