Bacteriological profile of diabetic foot ulcers and analysis of serum meteorin levels

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dc.contributor.authorErdogan, Esra
dc.contributor.authorYetisgen, Azize
dc.contributor.authorKeskin, Lezzan
dc.contributor.authorTanriverdi, Elif Seren
dc.contributor.authorUgur, Isilay Gokce Benk
dc.date.accessioned2026-04-04T13:37:27Z
dc.date.available2026-04-04T13:37:27Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractObjectiveWith the increase in the incidence of diabetes mellitus (DM) in recent years, diabetic foot ulcers (DFU), which are common and serious chronic complications of diabetes, have also become widespread. DFU is highly associated with a significant deterioration in quality of life as well as increased morbidity and mortality. Meteorin is a potent neurotrophic growth factor and shows antiangiogenic, antihyperalgesic, antinociceptive and neuroprotective effects. This study aimed to determine the possible relationship between meteorin, diabetes and diabetic foot ulcer by comparing the serum meteorin levels of healthy control group, DM patients and patients with diabetic foot ulcers.MethodsOur study included a total of 62 diabetic patients, 31 of whom had DFU, and 29 healthy individuals as a control group. Meteorin levels of the participants were measured using ELISA method in serum samples. Other laboratory and epidemiological data of the patients were obtained from the hospital database.ResultsIn the wound cultures taken from patients with DFU, the most commonly isolated bacteria were Staphylococcus aureus and Pseudomonas aeruginosa. Serum meteorin levels were found to be statistically significantly higher in diabetic patients as compared to the healthy control group, and among diabetic patients, those with DFU had significantly higher levels compared to those without DFU. A positive significant correlation was found between meteorin level and age, HbA1c, WBC, urea, sedimentation, CRP and ferritin.ConclusionThe results of our study, aimed at better understanding the biological functions and potential clinical applications of meteorin, suggest that meteorin could potentially be used as a biomarker for the development of DFU.
dc.identifier.doi10.1007/s11033-025-10427-0
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue1
dc.identifier.orcid0000-0001-8283-4516
dc.identifier.orcid0000-0003-4987-6612
dc.identifier.orcid0000-0003-1626-6033
dc.identifier.orcid0000-0002-0449-0356
dc.identifier.pmid40100449
dc.identifier.scopus2-s2.0-105000231073
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s11033-025-10427-0
dc.identifier.urihttps://hdl.handle.net/11616/109836
dc.identifier.volume52
dc.identifier.wosWOS:001447346000002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofMolecular Biology Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectDiabetic foot ulcers
dc.subjectMeteorin
dc.subjectStaphylococcus aureus
dc.subjectWagner classification
dc.titleBacteriological profile of diabetic foot ulcers and analysis of serum meteorin levels
dc.typeArticle

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