Preeklampside Serum Lipit, Lipoprotein Ve Lp(a) Düzeyleri
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Dosyalar
Tarih
2002
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
İnönü Üniversitesi Tıp Fakültesi Dergisi
Erişim Hakkı
Attribution 3.0 United States
Özet
Yüzyıldan fazla süren yoğun araştırmalara rağmen preeklampsi ve eklampsinin nedenleri tam olarak
anlaşılamamıştır. Muhtemelen plasental ve maternal doku arasındaki etkileşimler primer sebep olmasına karşın,
normal gebelikten farkının gerçek sebepleri halen açıklanamamıştır. Hamileliğe bağlı olarak lipit metabolizmasında
önemli değişimler ortaya çıktığı için, bu çalışmada preeklampside serum lipit ve Lp(a) değişimlerini araştırmayı
amaçladık.
Materyal ve Metod: Proteinüri ve yüksek kan basıncı (>140 / 90) değerlerine göre preeklampsili 35 hastayı
kapsayan çalışma grubu, kontrol grubu olarak 35 normal hamile kadın ile karşılaştırıldı. Her iki grup lipit
parametrelerine ilaveten anne yaşları, hamilelik süreçleri, kan basınçları ve vücut kitle indeksi (BMI) yönünden de
karşılaştırıldı. Serum HDL-C, total kolesterol ve trigliserit düzeyleri Olympus AU 600 cihazında enzimatikkolorometrik
yöntemle, Lp(a) seviyeleri Lp (a), apo A-I ve apo B düzeyleri Boehring nephelometer-100
analizör’de nefolometrik yöntemle çalışıldı.
Bulgular: Grupların lipoprotein profillerine göre preeklampside serum HDL-C, total kolesterol ve trigliserit
düzeyleri (sırasıyla 58 ± 10; 254 ± 47 ve 259 ± 66), normal hamile değerleriyle (46 ± 8; 219 ± 57 ve 198 ± 49)
kıyaslandığında önemli biçimde yüksek bulundu (p<0,05). Lp(a) seviyeleri de kontrole oranla preeklamptik
hamilelerde üç kat daha yüksekti (p<0.0001). Apo B düzeyleri preeklamptik gebelerde (115±22 mg/dL) kontrol
grubuna (97±15) göre anlamlı olarak yüksek bulunmuştur.(p< 0.0001) Apo A düzeyleri kontrole göre istatistiki
olarak anlamlı bulunmadı.
Tartışma:Preeklampside bulunan anormal yüksek lipit profilleri, uterus spiral arteriolleri gibi predispose
damarlarda patolojik lipit birikiminden sorumlu olabileceği için, bu sonuçlar önem arzedebilir.
After more than a century of intensive research preeclampsia and eclampsia remain an enigmatic set of conditions. Interaction between placental and maternal tissue is probably the primary cause, but the exact nature of the divergences from normal pregnancy remain unclear. Since there are some important alterations in lipid metabolism due to pregnancy, this study was undertaken in order to evaluate the serum lipid and Lp(a) changes in preeclampsia. Materials and methods:The study population was comprised of 35 patients with preeclampsia according to clinical findings of proteinuria and high blood pressure (>140 / 90) values compared to 35 normal pregnant women as control. Both groups were matched by maternal age, gestational period, blood pressures, and body mass index as well as lipid parameters. Serum total-C, HDL-C, ve TG levels were analised in Olympus AU 600 otoanalysor with enzimatic-calorimetric methods, and Lp (a), apo A-I ve apo B levels were analysed by Boehring nephelometer-100 analiyser with nepholometric method. Results:The lipoprotein profiles of the groups showed that serum HDL-C, total cholesterol, and triglyceride levels were significantly elevated in preeclampsia (58 ± 10; 254 ± 47 and 259 ± 66 respectively) compared to normal pregnant women (46 ± 8; 219 ± 57; and 198 ± 49 respectively ) (p<0,05). Lp(a) levels were 3 times higher in the preeclamptic pregnants compared to controls (p<0,0001). Apo B levels higher (115±22 mg/dL) in preeclamptic patients than control (97±15) and this was statistically significant. Turan ve ark 200 Conclusion: These findings may be important since the abnormal elevated lipid profiles in preeclampsia could be responsible for the pathological lipid deposition in predisposed vessels such as the uterine spiral arteries.
After more than a century of intensive research preeclampsia and eclampsia remain an enigmatic set of conditions. Interaction between placental and maternal tissue is probably the primary cause, but the exact nature of the divergences from normal pregnancy remain unclear. Since there are some important alterations in lipid metabolism due to pregnancy, this study was undertaken in order to evaluate the serum lipid and Lp(a) changes in preeclampsia. Materials and methods:The study population was comprised of 35 patients with preeclampsia according to clinical findings of proteinuria and high blood pressure (>140 / 90) values compared to 35 normal pregnant women as control. Both groups were matched by maternal age, gestational period, blood pressures, and body mass index as well as lipid parameters. Serum total-C, HDL-C, ve TG levels were analised in Olympus AU 600 otoanalysor with enzimatic-calorimetric methods, and Lp (a), apo A-I ve apo B levels were analysed by Boehring nephelometer-100 analiyser with nepholometric method. Results:The lipoprotein profiles of the groups showed that serum HDL-C, total cholesterol, and triglyceride levels were significantly elevated in preeclampsia (58 ± 10; 254 ± 47 and 259 ± 66 respectively) compared to normal pregnant women (46 ± 8; 219 ± 57; and 198 ± 49 respectively ) (p<0,05). Lp(a) levels were 3 times higher in the preeclamptic pregnants compared to controls (p<0,0001). Apo B levels higher (115±22 mg/dL) in preeclamptic patients than control (97±15) and this was statistically significant. Turan ve ark 200 Conclusion: These findings may be important since the abnormal elevated lipid profiles in preeclampsia could be responsible for the pathological lipid deposition in predisposed vessels such as the uterine spiral arteries.
Açıklama
İnönü Üniversitesi Tıp Fakültesi Dergisi
9(3) 199-203 (2002)
Anahtar Kelimeler
Preeklampsi, Lipit, Lipoprotein, Lp(a), Preeclampsia, Lipids
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Turan, Fahri ;Sezgin, Nurzen ;Özerol, Elif ;Karabulut, Aysun Bay ; Kafkaslı, Ayşe ;Akbaşak, Bülbin Sunar ;İnönü Üniversitesi Tıp Fakültesi Dergisi 9(3) 199-203 (2002)