Beneficial effects of melatonin on diaphragmatic contractility and fatigability in Escherichia coli endotoxemic rats

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dc.authoridyilmaz, zehra/0000-0002-9523-7718
dc.authorwosidyılmaz, zehra/ABF-5526-2020
dc.contributor.authorKurcer, Z
dc.contributor.authorIraz, M
dc.contributor.authorKelesyilmaz, N
dc.contributor.authorKilic, N
dc.contributor.authorOlmez, E
dc.date.accessioned2024-08-04T20:15:21Z
dc.date.available2024-08-04T20:15:21Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSepsis impairs diaphragmatic contractility and endurance capacity and increases diaphragmatic fatigability. Several investigations have shown that administration of a number of free radical scavengers, such as N-acetylcysteine (NAC), protects the diaphragm from the development of endotoxin-mediated diaphragmatic dysfunction. The aim of this study was to evaluate the effects of melatonin (CAS 73-31-4), a naturally occurring potent antioxidant, on diaphragmatic contractility and lipid peroxidation as a marker of oxidative stress in endotoxemic rats. Rats were randomly divided into four groups: control group, endotoxemic group, melatonin group and endotoxemic plus melatonin group. Melatonin was administered by intraperitoneal injection 30 min before endotoxin inoculation to animals. Diaphragmatic function and malondialdehyde (MDA) level analysis as an indicator of lipid peroxidation were assessed 17 h after endotoxin or saline inoculation. Endotoxemia decreased the tensions generated in response to all frequencies of stimulation and increased the development of diaphragm fatigue and diaphragmatic MDA levels. The effects of endotoxemia on diaphragmatic contractions and fatigability were reversed and returned to control levels by melatonin administration. However, melatonin did not prevent the increase in muscle MDA content. In conclusion, the present study demonstrated that melatonin attenuated the endotoxin-induced impairment of diaphragm function. This effect of melatonin does not seem to be related to its antioxidant properties.en_US
dc.identifier.endpage95en_US
dc.identifier.issn0004-4172
dc.identifier.issn1616-7066
dc.identifier.issue2en_US
dc.identifier.pmid16572923en_US
dc.identifier.scopus2-s2.0-33645108432en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage90en_US
dc.identifier.urihttps://hdl.handle.net/11616/94322
dc.identifier.volume56en_US
dc.identifier.wosWOS:000236770000006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofArzneimittelforschung-Drug Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectandoxidantsen_US
dc.subjectCAS 73-31-4en_US
dc.subjectendotoxemiaen_US
dc.subjectmelatonin, effect on diaphragmatic ftmctionen_US
dc.titleBeneficial effects of melatonin on diaphragmatic contractility and fatigability in Escherichia coli endotoxemic ratsen_US
dc.typeArticleen_US

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